目的 探讨18F-FDG PET/CT对儿童神经母细胞瘤(neuroblastoma， NB)近期疗效评估的应用价值。方法 回顾性分析我院2012-04至2015-04收治的14例行18F-FDG PET/CT检查的NB患儿临床资料，观察18F-FDG PET/CT对NB患儿疗效的评估及对复发、转移病灶的检出情况。结果 14例NB患儿共行18例次18F-FDG PET/CT检查，其中8例次显示不同程度、不同部位的FDG异常摄取增高灶，指导临床及时调整了治疗。18F-FDG PET/CT改变了1例患儿分期， 由初始Ⅳs期提高至Ⅳ期。4例复发患儿共17处病灶，18F-FDG PET/CT对复发、转移病灶的检出率为88.2%(15/17)，遗漏1处颅内微小转移灶和1例骨髓微小转移。结论 18F-FDG PET/CT对儿童NB近期疗效的评估具有重要价值，可作为NB患儿随访的辅助检查之一。
Abstract
Objective To investigate the clinical value in the evaluation of the short-term efficacy of 18F-FDG PET/CT in children with neuroblastoma (NB).Methods Clinical data of 14 NB patients undergoing 18F-FDG PET/CT examination were recruited from April 2012 to April 2015 in this hospital. We evaluated the therapeutic efficacy in NB children and detected recurrent lesions.Results 14 NB children received totally 18 times 18F-FDG PET/CT examinations. Among them, 8 cases showed different degree and different parts with abnormal increased uptake of FDG, which guided to adjusting clinical treatment promptly.18F-FDG PET/CT changed one case’s stage, increasing from the initial stage Ⅳs to stage Ⅳ. 4 children who suffered relapse had a total of 17 lesions. The detection rate of 18F-FDG PET/CT for recurrent and metastatic lesions was 88.2% (15/17), missing one small intracranial metastasis and one case of bone marrow micro-metastasis.Conclusions 18F-FDG PET/CT has an important value in the evaluation of the short-term efficacy of NB children, and can be used as follow-up examination of NB in children.
关键词
神经母细胞瘤 /
正电子发射型计算机断层扫描 /
儿童 /
疗效评估
Key words
neuroblastoma /
positron emission computerized tomography /
children /
efficacy evaluation
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