目的 探讨中国人群高脂血症与良性阵发性位置性眩晕 (benign paroxysmal positional vertigo,BPPV) 复发的关系。方法 系统性检索国内外公开发表的有关中国人群高脂血症与BPPV复发关系的文献,检索数据库包括中国知网、万方数据知识服务平台、PubMed、Embase 和Google Scholar,时间范围从各数据库建库至2015年12月,共检索到16篇文献。采用Meta分析方法计算高脂血症与BPPV复发风险的合并OR(95%CI)值。结果 最终纳入文献6篇共计944例患者,Meta分析结果表明,高脂血症并不能增加BPPV复发的风险(OR=2.12,95%CI:0.77～5.89)。Begg秩相关法(Z=-0.98,P=0.383)和Egger 回归法(t=-0.44,P=0.680)结果均显示本次Meta分析不存在发表偏倚。结论 现有研究尚不能证明高脂血症是BPPV复发的独立危险因素。
Abstract
Objective To study the relationship between hyperlipidemia and recurrence of BPPV in Chinese population.Methods A systematic literature search for hyperlipidemia and risk of BPPV recurrence in the Chinese population was carried out. The literature databases including Chinese National Knowledge Infrastructure, Wanfang, PubMed, Embase and Google Scholar. Time range was from the founding of each database to December 2015 and a total of 16 research papers were collected. Meta-analysis was conducted to calculate pooled odds ratio and corresponding 95%CI.Results Six studies were included in the meta-analysis, with a number of 944 BPPV cases. Hyperlipidemia did not show increase the risk of BPPV recurrence (OR=2.12,95%CI:0.77～5.89). Begg rank correlation method (Z=-0.98,P=0.383) and Egger regression (t=-0.44,P=0.680) Results showed that the meta-analysis does not have publication bias. Conclusions The present study cannot prove that hyperlipidemia is an independent risk factor for recurrence of BPPV.
关键词
良性阵发性位置性眩晕 /
复发 /
高脂血症 /
Meta分析
Key words
benign paroxysmal positional vertigo(BPPV) /
recurrence /
hyperlipidemia /
meta-analysis
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参考文献
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