目的 观察白藜芦醇软胶囊对糖尿病患者血糖及早期视网膜病变的疗效。方法 采用数字表法随机将60例糖尿病早期视网膜病变患者分为A、B、C、D 4组:每组15例, 前3组均在基础治疗上加白藜芦醇软胶囊,其中A组:250 mg/次,口服,2次/d;B组:350 mg/次,口服,2次/d;C组:500 mg/次,口服,2次/d,治疗12周。D组为对照组(基础治疗:运动干预、饮食控制、胰岛素及口服降糖药),比较治疗前后1、8、10、12周末对早期视网膜病变患者的空腹血糖、糖化血红蛋白(hemoglobinA₁c,HbALc)、胰岛素进行比较;并在用药前及12周末,采用视网膜荧光造影(fundus fluorescence angiography,FFA)对患者的微血管瘤数、出血灶和渗出灶面积变化进行比较。结果 C组治疗前后比较,空腹血糖:(8.6±0.812)mmol/ L比(6.7±0.714) mmol/L,t=4.752,P=0.033;HbALc:(8.7±0.341)%比(7.2±0.426) %,t=5.542,P=0.031;胰岛素:(32.4±0.342) pmol/ml比(28.3±0.123) pmol/ml,t=6.459,P=0.038;降血糖有效率为66.76%。治疗后C组与D组微血管瘤数、出血灶面积、渗出灶面积均数分别为(16.86±1.75) 个比(10.06±1.29) 个,t=4.624, P＜0.05;(2.24±0.23) mm²比(1.45±0.22) mm²,t=2.532, P＜0.05;(1.40±0.15) mm²比(1.01±0.23) mm²,t=2.605, P＜0.05;治疗后微血管瘤数减少,出血灶面积和渗出灶面积缩小。结论 白藜芦醇软胶囊对糖尿病患者血糖及早期视网膜病变的疗效呈剂量依赖性,其改善糖尿病患者的血糖及早期视网膜病变有效率C组优于B组,B组优于A、D组。

Objective To study the efficacy of resveratrol soft capsules on fasting blood glucose and early diabetic retinopathy(DR).Methods 60 diabetic patients with DR were randomly divided into 4 groups: A, C, B and D by using digital table method.15 cases in each group.The first three groups received basic treatment plus resveratrol soft capsules, Group A: 250 mg/ead time, orally, twice/day; Group B: 350 mg/each times, orally,twice/day; Group C: 500 mg/each time, orally, twice/day for 12 weeks. D group was the control group (basic treatment: exercise intervention, diet control, insulin and oral hypoglycemic agents), compared before and after treatment 1,8,10,12 weekend DR fasting glucose.And before medication and 12 weeks,retinal fluorescein angiography (fundus fluorescence angiography FFA) was used to detect microvascular changes in the patient’s capillary hemangioma,hemorrhage and leakage area for comparison.Results In C group,after treatment ,FPG(8.6±0.812)mmol/L ratio(6.7±0.714)mmol/L,t=4.752,P=0.037;HbALc:(8.7±0.341)% versus(7.2±0.426)%,t=5.542,P=0.031,ISN:(32.4 ± 0.341)pmol/ml versus (28.3±0.132) pmol/ml,t=6.459,P=0.038,In after group C and D, capillary hemangioma, hemorrhage focal area and leaking focal area were (16.86±1.75)N versas (10.06±1.29)N,t=4.624, P＜0.05;(2.24±0.23)mm² versas(1.45±0.22) mm²,t=2.532, P＜0.05,(1.40±0.15) mm² versas(1.01±0.23) mm²,t=2.605, P＜0.05.After treatment, the number of capillary hemangioma was decreased, the area of hemorrhage and the area of leakage were reduced.Conclusions The effect of resveratrol on blood glucose and early retinopathy in diabetic patients is dose dependent,and the effective rate in group C is better than that in group B, and group B was better than groups A and D.