目的 探究结直肠癌(coloretal cancer,CRC)患者术前血清肿瘤标志物癌胚抗原(carcinoembryonic antigen,CEA)及糖类抗原19-9(carbohydrate antigen 19-9,CA19-9)检测结果与CRC临床病理学特征的关系。方法 收集武警总医院肛肠病研究所2010-01至2016-04行CRC根治性手术治疗的475例的病历资料,将术前CEA及CA19-9检测结果与术后临床病理分期结果及临床资料进行统计分析,并研究其相关性。结果 475例中,术前血清CEA阳性198例(41.68%),CA19-9阳性109例(22.95%)。CEA和CA19-9阳性率与CRC患者性别、年龄、吸烟史、梗阻、肿瘤位置、肿瘤大小、肿瘤类型均无相关性。CEA和CA19-9阳性率与CRC TNM分期、临床分期、肿瘤分化程度、癌结节、脉管浸润有相关性(P<0.05),且CRC患者中CEA 和CA19-9阳性率均与肿瘤TNM 分期和肿瘤临床分期呈正相关(P<0.05)。结论 术前CEA和CA19-9的血清学检测在一定程度上具有预判CRC临床及病理分期的作用,从而为临床上CRC患者后续治疗和预后判断提供一定帮助。
Abstract
Objective To investigate the relationship between preoperative detection results of serum tumor markers carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9(CA19-9) and clinical pathological characteristics of patients with colorectal cancer(CRC).Methods The medical records of 475 CRC patients who had received radical surgery between January 2010 and April 2016 at our hospital were collected before thepreoperative serum CEA and CA19-9 test results, clinical pathologic staging results, and clinical data were statistically analyzed to study the correlation.Results Among the 475 patients, 198 cases of preoperative serum CEA tested positive (41.68%),so did 109 cases of preoperative serum CA19-9(22.95%). No correlation was found between the positive rates of CEA and CA9-9 and CRC patients’ gender, age, smoking history, intestinal obstruction, tumor location, tumor size, and histological type.The positive rates of CEA and CA19-9 were not only correlated with TNM stages,clinicopathologic stages,histologic tumor grade, tumor deposit and blood vessel invasion (P<0.05), but also positively correlated with TNM stages and clinicopathologic stages of CRC (P<0.05).Conclusions Preoperative serological detection of CEA and CA19-9 can facilitate the prediction of CRC clinical stages while provide clinical support for follow-up treatment and prognosis of patients with CRC.
关键词
结直肠癌 /
肿瘤标志物 /
癌胚抗原 /
糖类抗原19-9
Key words
colorectal cancer /
tumor markers /
carcinoembryonic antigen /
carbohydrate antigen 19-9
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