目的 调查专项整治前后我院骨科Ⅰ类切口手术抗菌药物预防性使用情况,为后续管理提供依据。方法 采用回顾性调查法,抽取2010-08-01至2010-08-07(专项整治前)和2014-08-01至2014-08-07(专项整治后)全部骨科Ⅰ类切口手术病例,对预防用抗菌药物使用率、用药品种、持续时间、使用频度(DDDs)、药物利用指数(DUI)、用药费用等数据进行统计、分析。结果 专项整治后我院骨科Ⅰ类切口手术预防用抗菌药物使用率由整治前的100%下降到53.5%,抗菌药物品种选择以第一、二代头孢菌素为主,用药持续时间、使用频度和药物利用指数趋于合理,抗菌药物人均费用由整治前的921.3元下降为319.2元。结论 通过加强围术期预防用药的管理,采取有效的干预措施,可促进围术期抗菌药物应用的规范化、合理化。

Objective To investigate the use of antibiotics among orthopedic patients with type Ⅰ incision operation before and after the specific rectification initiative in our hospital in order to provide reference for subsequent management.Methods The data on the percentage、DDDs、DUI、consumption、category and duration of antibiotics used in orthopedic patients with type I incision operation between August 1 and August 7, 2010(before the special rectification)and between August 1 and August7,2014(after the special rectification)were retrospectively analyzed.Results After the special rectification initiative,the percentage of antibiotics use in orthopedic patients with type I incision operation decreased from 100% to 53.5%, cephalosporins of the first and second generation were the most-prescribed antibiotics, and the duration、DDDs、DUI of antibiotics use became more standard. The per capita cost of antibiotics decreased from 921.3 yuan to 319.2 yuan.Conclusions The standard and reasonable application of antibiotics during the perioperative period can be promoted by strengthening the management of preventive drug application and adopting proper interventional measures.