赭曲霉毒素A(ochratoxin A, OTA)是一种主要由纯绿青霉、碳黑曲霉和赭曲霉产生的真菌毒素,广泛存在于食品、农产品和动物饲料中,因此OTA与人类健康的关系备受关注。研究发现,OTA具有肾毒性、肝毒性、神经毒性、免疫毒性和致畸性[1]。国际癌症研究中心(International Agency for Research on Cancer, IARC)1993年把OTA定为“B级人类可能致癌物”[2]。但是,迄今为止有关OTA的致癌作用机制尚不完全清楚。笔者主要就目前备受关注的OTA致癌机制进行综述。
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