目的 通过Meta分析评价长期连续配戴硅水凝胶与水凝胶软性亲水接触镜所导致的角膜基质浸润的发生率,从临床角度评价两者的生物相容性。方法 遵照纳入排除标准检索PubMed和CNKI数据库获取相关文献并筛选文献后,进行资料提取和合格研究质量评价再使用Stata 12.0软件进行Meta分析。结果 最终纳入4项前瞻性比较研究。基于该4项研究的结果表明,连续配戴硅水凝胶软性镜所致角膜基质浸润的风险相比连续配戴水凝胶软性镜所致角膜基质浸润降低了77%(OR=0.23,95%CI=0.14~0.36)。长期连续配戴硅水凝胶软性亲水接触镜导致角膜基质浸润的发生率为0.3%,长期连续配戴水凝胶软性亲水接触镜导致角膜角膜基质浸润的发生率为1.4%。结论 虽然长期连续配戴硅水凝胶与配戴水凝胶软性镜相比较,前者导致角膜基质浸润的风险低,但是仍需指导患者正确使用软性镜,并注意加强随访。
Abstract
Objective To estimate the incidence of corneal infiltrates among chronic wearers of silicone hydrogel soft contact lens and hydrophilic soft contact lens and to evaluate the biocompatibility from a clinical perspective.Methods A systematic search was conducted using such online databases as Pub Med and CNKI. After literature selection, data extraction, and methodological quality assessment, a meta-analysis was performed using the Stata 12.0 software.Results Finally four prospective comparative studies were included. Wearers who used silicone hydrogel soft contact lens were 77 percent less vulnerable to corneal infiltrates than those who used hydrophilic contact lens (OR=0.23, 95% CI=0.23-0.36). The incidence of corneal stromal infiltration among users of silicone hydrogel soft contact lens was 0.3%, compared with 1.4% among users of hydrophilic soft contact lens.Conclusions Chronic wearers of silicone hydrogel soft contact lens are at lower risk of corneal infiltrates than users of hydrophilic soft contact lens, but it is important for ophthalmologists to instruct patients to use soft contact lens properly and care about the follow-up of patients.
关键词
软性镜 /
连续配戴 /
角膜基质浸润 /
Meta分析
Key words
soft contact lens /
continuous wear /
corneal infiltrate /
meta-analysis
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参考文献
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基金
十三五国家重点研发计划(课题编号:2016YFC1103202)
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