目的 分析研究老年人长期服用阿司匹林与胃黏膜组织状态、幽门螺杆菌感染率的关系。方法 选取91458部队医院2015-01至2016-12期间服用阿司匹林治疗的68例老年人为观察组,同时期的68例中年患者为对照组,然后统计并比较两组中不同服用时间患者的幽门螺杆菌感染率、胃黏膜血流情况、胃黏膜组织氧化应激指标,同时比较观察组中不同服用时间者的检测结果。结果 观察组的幽门螺杆菌总感染率(63.24%)显著高于对照组(38.24%),且不同服用时间患者的感染率均高于对照组。其中,服用时间在5年以下的观察组幽门螺杆菌总感染率为52.63%,显著高于对照组(28.95%);服用时间在5年以上的观察组幽门螺杆菌总感染率为76.67%,同样显著高于对照组(50.00%)。服用阿司匹林5年以下或者5年及以上的观察组患者胃大弯、小弯、前壁、后壁各不同部位的胃黏膜血流量均显著低于对照组。同样,服用阿司匹林不同时间的观察组患者胃黏膜组织氧化应激指标中SO(superoxide dismutase)表达水平均显著低于对照组,而NO(Nitric oxide)及MDA(Methylene dioxyamphetamine)的表达水平则均显著高于对照组。此外,不同服用时间者的以上各指标检测结果也都存在显著性差异(P＜0.05),差异具有统计学意义。结论 老年人长期服用阿司匹林可导致胃黏膜组织状态较差与幽门螺杆菌感染率升高,且服用时间越长者其状态相对越差,因此应对老年长期服用阿司匹林者进行针对性干预。
Abstract
Objective To study the relationships between chronic use of aspirin and gastric mucosa tissue state,Helicobacter pylori infection rate among elderly patients.Methods Sixty-eight elderly patients treated with aspirin at our hospital between January 2015 and December 2016 were selected as the observation group,while another 68 middle-aged patients treated at the same time served as the control group.The Helicobacter pylori infection rates,gastric mucosa blood flow and gastric mucosa tissue oxidative stress indexes of two groups with different durations of medication were analyzed and compared,so were the detection Results of patients in the observation group who took aspirin for different lengths of time.Results The Helicobacter pylori infection rate of observation group (63.24%) was significantly higher than that of control group (38.24%), and the infection rates of patients with different durations of medication were higher than those of control group. Specifically, the infection rate of patients in observation group (52.63%) who had taken the drug less than 5 years was significantly higher than that of control group (28.95%), and the infection rate of patients in observation group (76.67%) who had taken the drug more than 5 years was also significantly higher than that of control group (50.00%). The gastric mucosa blood flow of the greater curvature, lesser curvature, anterior gastric wall, and posterior gastric wall of observation group was lower than that of control group regardless of the duration of medication. Similarly, among the gastric mucosa tissue oxidative stress indexes, SOD (superoxide dismutase) level was much lower than that of control group, while the levels of NO (nitric oxide) and MDA (Methylene dioxyamphetamine) were both higher than those of control group. Besides, the detection Results of all these indexes in the observation group with different durations of medication were significantly different (P<0.05).Conclusions Chronic use of aspirin by elderly patients can lead to a worse state of gastric mucosa and a higher Helicobacter pylori infection rate,so targeted intervention is needed.
关键词
老年患者 /
长期服用阿司匹林 /
胃黏膜组织状态 /
幽门螺杆菌感染率
Key words
elderly patients /
chronic use of aspirin /
gastric mucosa tissue state /
Helicobacter pylori infection rate
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