目的 探讨颅脑外伤患者血浆D-二聚体(D-dimer,D-D)和全血白细胞(white blood cell, WBC)参数的相关性。方法 回顾性统计分析医院2014-06至2016-05收治的246例颅脑外伤患者,随机选取35例作为健康对照组,颅脑外伤患者住院后首次检测D-D及血细胞分析,统计D-D异常升高程度和白细胞参数相关性。结果 颅脑外伤患者D-D浓度为(8.20±5.93)mg/L,WBC为(12.54±3.59)×109/L,NEU%为(89.97±9.40)%,NEU#为(10.82±3.22)×109/L,明显高于健康对照组的(0.19±0.12)mg/L、(6.15±0.92)×109/L、NEU%为(60.28±9.05)%、NEU#为(4.36±0.11)×109/L,差异均有统计学意义(P<0.01)。D-D升高程度与血细胞参数中WBC、NEU%、NEU#呈正相关(P<0.01),D-D升高程度与血细胞参数中LYM%、LYM#呈负相关(P<0.05)。结论 颅脑外伤患者血浆D-D和白细胞计数均高于健康人,而且D-D和白细胞呈正相关性。
Abstract
Objective To explore the significance of increased levels of plasma D-dimer (D-D) and relevant white blood cell (WBC) variation for patients with brain trauma.Methods Medical data on two hundred and forty-six cases of patients with craniocerebral trauma was retrospectively analyzed, while another thirty-five healthy people were randomly selected as control. D-D levels and whole blood cells were tested for the first time after hospitalization. Abnormally elevated D-D levels and correlated changes of WBC parameters were statistically analyzed.Results For patients with traumatic brain injury, the D-D concentration was (8.20±5.93) mg/L, WBC(12.54±3.59)×109/L, NEU%(89.97±9.40)% and NEU# was (10.82±3.22)×109/L, which were significantly higher than in the healthy control group(0.19±0.12) mg/L, (6.15±0.92)×109/L, (60.28±9.05)% and (4.36±0.11)×109/L (P<0.01) respectively. The degree of elevated D-D was positively correlated with WBC, NEU% and NEU# in blood cell parameters (P<0.01), but negatively correlated with LYM% and LYM# (P<0.05). The difference was statistically significant.Conclusions The degree of D-D and WBC of patients are higher than those of healthy people. The degree of elevated D-D is positively correlated with WBC for patients with brain trauma.
关键词
颅脑外伤 /
D-二聚体 /
白细胞参数 /
相关性
Key words
traumatic brain injury /
D-dimer /
leukocyte parameter /
correlation
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