目的 比较经空气压缩雾化吸入与超声雾化吸入布地奈德联合异丙托溴铵治疗急性感染性喉炎的临床疗效,以及对患者白细胞介素-4(interleukin-4)和免疫球蛋白E(immunoglobulin E,IgE)水平的影响。方法 选取2015-01至2016-06接受治疗的120例急性感染性喉炎患者作为研究对象,按照随机数字表法随机分为对照组60例和观察组60例。常规治疗基础上,所有患者均给予布地奈德联合异丙托溴铵雾化吸入治疗。对照组患者给予空气压缩雾化吸入治疗,观察组患者给予超声雾化吸入治疗。疗程结束后,比较对照组和观察组患者临床疗效、临床症状改善时间及血清IL-4、IgE水平。结果 临床疗效显示,观察组患者治疗总有效率明显高于对照组(95.0% vs 83.3%,P<0.05)。与对照组相比,观察组咳嗽、声音嘶哑、喉鸣等临床症状改善时间显著缩短[(3.3±0.8)d vs (4.2±1.0) d,(3.5±0.6)d vs (4.3±1.2) d,(6.4±0.9)d vs (7.9±1.4) d,P均＜0.05]。治疗后,与对照组相比,观察组患者血清IL-4、IgE水平明显降低[(7.24±1.83)ng/L vs (15.19±2.36) ng/L,(50.43±9.62)μg/L vs (82.25±10.45)μg/L,P均＜0.05]。结论 对于急性感染性喉炎,与空气压缩雾化吸入布地奈德联合异丙托溴铵治疗相比,超声雾化吸入治疗总有效率高,临床症状改善时间短,血清IL-4、IgE降低更明显,具有更显著优势。

Objective To compare the curative efficacy of budesonide in combination with ipratropium bromide administrated by air compression atomizing inhalation and ultrasonic atomizing inhalation respectively in patients with acute infectious laryngitis and its effects on interleukin-4 (IL-4) and immunoglobulin E (IgE).Methods 120 patients with acute infectious laryngitis who received therapy in our hospital from January 2015 to June 2016 were selected as subjects. According to the random number table, those patients were randomly divided into the control group (n=60) and the observation group (n=60). Besides conventional treatments, all patients were treated with budesonide in combination with ipratropium bromide administrated by atomizing inhalation. The control group was given air compression atomizing inhalation, while the observation group was given ultrasonic atomizing inhalation. Then, the curative efficacy, time taken by improvement of clinic symptoms and levels of serum IL-4, IgE were compared between the two groups.Results The total therapeutic efficacy rate in the observation group was statistically higher than that in the control group (95.0% vs 83.3%, P<0.05). In comparison with the control group, the time taken by improvement of cough, hoarseness and laryngeal stridor in the observation group was statistically shorter respectively [(3.3±0.8) d vs (4.2±1.0) d, (3.5±0.6)d vs (4.3±1.2) d, (6.4±0.9)d vs (7.9±1.4) d, all P<0.05)]. After the treatment, levels of serum IL-4 and IgE in the observation group were statistically lower than those in the control group [(7.24±1.83) ng/L vs (15.19±2.36) ng/L, (50.43±9.62) μg/L vs (82.25±10.45) μg/L, both P<0.05)].Conclusions For patients with acute infectious laryngitis, ,ultrasonic atomizing inhalation has not only a higher total therapeutic efficacy rate, shorter improvement time of clinic symptoms and lower levels of IL-4, IgE than budesonide in combination with ipratropium bromide administrated by air compression atomizing inhalation, but also some other advantages.