目的 观察急性心肌梗死(acute myocardial infarction,AMI)患者血栓调节蛋白(thrombomodulin, TM)的变化与超敏肌钙蛋白T(hypersensitivity troponin T, hsTnT)的相关性。方法 采用病例对照研究方法,选择符合入选标准的AMI患者(AMI组)和健康人(对照组)各30例(名),采集血液标本,采用酶联免疫检测法检测TM的浓度,利用SPSS统计软件进行数据分析。结果 AMI组TM、肌酐(简称Cr)及TM/Cr均大于对照组,差异有统计学意义(P<0.05);TM与hsTnT呈正相关(r=0.524, P<0.05),TM/Cr与hsTnT呈正相关(r=0.725,P<0.05)。结论 AMI患者TM明显增加,TM与hsTnT呈正相关,且TM/Cr可做为诊断急性心肌梗死的指标。
Abstract
Objective To study the variation of thrombomodulin (TM) and the correlations with the hypersensitivity troponin T(“hsTnT”for short) in patients with acute myocardial infarction(AMI).Methods The case-control method was used to recruit 30 subjects with AMI and another 30 healthy people as the control group. Enzyme-linked immunoassays were used to detect TM and SPSS was used for data analysis.The correlations between TM and hsTnT were studied.Results TM,creatinine and TM/creatinine ratio were increased in patients with AMI (P<0.05), and TM and TM/Cr ratio were positively correlated with hsTnT (r=0.524,P<0.05;r=0.725,P<0.05).Conclusions TM is increased in patients with AMI, and TM/Cr ratio can be used as a molecular marker ofacute myocardial infarction.
关键词
血栓调节蛋白 /
血栓调节蛋白/肌酐比值 /
急性心肌梗死
Key words
thrombomodulin /
thrombomodulin/creatinine ratio /
acute myocardial infarction
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参考文献
[1] 沈法荣,钟 诚. 心肌梗死诊断标准心电图变化最新指南解读[J].心电学杂志, 2010, 29(2): 88-91.
[2] Sapru A, Calfee C S, Liu K, et al. Plasma soluble thrombomodulin levels are associated with mortality in the acute respiratory distress syndrome [J]. Intensive Care Med, 2015, 41 (3):470-478.
[3] Yasuaki D, Masuo O, Masaya S,et al. Circulating thrombomodulin levels are related to latent progression of atherosclerosis in hypertensive patients [J]. Hypertens Res,2003,26(6):479-483.
[4] Yutaka E, Satoshi G, Hiroyasu I, et al.Post-marketing surveillance data of thrombomodulinalfa: sub-analysis in patients with sepsis-induced disseminated intravascular coagulation[J]. J Intensive Care, 2014, 2(30):1-10.
[5] 陈聿峰.血栓调节蛋白与冠心病的关系[J]. 血栓与止血学,2014,20(6):347-349.
[6] 江 雁,穆 红, 唐志琴.血栓调节蛋白及细胞间粘附因子检测在急性冠脉综合征中的临床应用[J]. 哈尔滨医药, 2009,29(3):1-3.
[7] 张 蕾,孙旦澄,张燕香,等.脑梗死和心肌梗死患者血栓调节蛋白的检测及临床应用[J].检验医学,2005,20(1):40-41.
[8] 樊淑珍,赵国君.超敏肌钙蛋白T定量与急性冠状动脉综合征病人预后的相关性研究[J].内蒙古医科大学学报,2016,38(4):316-324.
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