目的 调查北京市健康体检人群血清25(OH)D3水平,并研究其与季节、性别、BMI、钙、磷、甲状旁腺激素(PTH)的关系。方法 采用电化学发光免疫法对北京市825名体检人员进行25(OH)D3、PTH测量,并按性别、季节、年龄、BMI等方面分析25(OH)D3水平,利用线性回归方法分析变量间相关关系。结果 北京市体检人群血清25(OH)D3在人群中呈正偏态分布,中位数为12.31(8.57,16.70)ng/ml,统计显示397人(48.1%)处于缺乏状态(＜12 ng/ml),314人(38.1%)处于不足状态(12～20 ng/ml);血清25(OH)D3夏秋季含量最高,春季最低;血清25(OH)D3性别间差异明显,年龄＜60岁男性25(OH)D3含量明显高于女性(P＜0.01);超重及肥胖女性人群血清25(OH)D3显著低于正常体重女性人群(P＜0.05);女性25(OH)D3与BMI呈负相关关系(r=-0.143,P=0.015);整体人群25(OH)D3与PTH呈负相关关系(r=-0.234,P＜0.01)。结论 北京市体检人群血清25(OH)D3普遍缺乏,建议针对不同季节、性别、BMI,为相应人群提供维生素D补充方案,达到疾病的一级预防。
Abstract
Objective To investigate serum 25(OH)D3 level of adults and its correlations with the season, gender, BMI, calcium, phosphorous and PTH of physical examinees in Beijing.Methods The levels of serum 25(OH)D3 and PTH data of 825 physical examinees were acquired by Electro-Chemiluminescence Immunoassay (ECLI). The levels of 25(OH)D3 were analyzed in connection with the season, gender and BMI. Linear regressions were used to study the relationships between 25(OH)D3 and other variables.Results Serum 25(OH)D3 followed a skewed distribution with a median of 12.31(8.57,16.70)ng/ml. In our study, 397 samples (accounting for 48.1% of total samples) were diagnosed as severe deficiency of 25(OH)D3 (<12 ng/ml) while another 314 samples (38.1%) as moderate deficiency of 25(OH)D3 (12-20 ng/ml). The level of serum 25(OH)D3 was significantly higher in summer and autumn and was at the bottom in spring.There was significant difference in the level of serum 25(OH)D3 between males and females, with the level among men (aged below 60) evidently higher than among women (P＜0.01). Serum 25(OH)D3 level was significantly lower among obese and overweight women than among women of normal weight (P＜0.05). Female serum 25(OH)D3 level was negatively correlated with BMI (r=-0.143,P=0.015), so was sample 25(OH)D3 with PTH (r=-0.234,P＜0.01).Conclusions Serum 25(OH)D deficiency is common among physical examinees in Beijing. It is recommended that specific vitamin D supplementation for different seasons, sex and BMI be initiated for primary prevention.
关键词
血清25羟基维生素D /
性别 /
季节 /
体重指数
Key words
serum25(OH)D3 /
sex /
season /
BMI
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