[1] Gerald R,Nathalie S,Florence F, et al.Temozolomide treatment in aggressive pituitary tumors and pituitary carcinomas:a French multicenter experience[J] .Clin Endocrinol Metab, 2010,95(10):4592-4599. [2] Bianchi A,Valentini F,Luorio R,et al.Long-term treatment of somatostatin analog-refractory growth hormone-secreting pituitary tumors with pegvisomant alone or combined with long-acting somatostatin analogs:a retrospective analysis of clinical practice and outcomes[J] .Exp Clin Cancer Res, 2013,32:40. [3] Daniel C R,Maria F.Somatostatin receptor ligands and resistance to treatment in pituitary adenomas[J] .J Mol Endocrinol,2014,52:223-240. [4] Molitch M E.Pharmacologic resistance in prolactinomapatients[J] . Pituitary,2005,8:43-52. [5] Mark E. Molitch:management of medically refractory prolactinoma[J] .Neurooncol, 2014,117:421-428. [6] Juan J A,Sang R C,Won J, et al.Anti-proliferative effects and cell death mediated by two isoforms of dopamine D2 receptors in pituitary tumor cells[J] .Molecular and Cellular Endocrinology,2003, 206: 49-62. [7] Picetti R,Saiardi A,Abdel S T, et al.Dopamine D2 receptors in signal transduction and behavior[J] . Crit Rev Neurobiol,1997, 11:121-142. [8] Missale C,Nash S R,Robinson S W, et al.Dopamine receptors: from structure to function[J] .Physiol Rev,1998, 78:189-225. [9] Gillam M P, Molitch M P, Lombardi G, et al. Advances in the treatment of prolactinomas[J] . Endocr Rev,2012, 27:485–534. [10] Melmed S, Casaneuva F F, Hoffman A R, et al.Diagnosis and treatment of hyperprolactinemia. an endocrine society clinical practice guideline[J] . Clin Endocrinol Metab, 2011,96:273-288. [11] Roth B L.Drugs and valvular heart disease[J] . Engl J Med,2007, 356:6-9. [12] Antonini A, Poewe W.Fibrotic heart-valve reactions to dopamine-agonist treatment in Parkinson’s disease[J] . Lancet Neurol,2006, 6:826-829. [13] Trifiro’ G, Mokhles M M, Dieleman J P,et al.Risk of cardiac valve regurgitation with dopamine agonist use in Parkinson’s disease and hyperprolactinemia[J] .A multi-country, 2012, 35:159-171. [14] Oh M C, Aghi M K .Dopamine agonist-resistant prolactinomas[J] .Neurosurg,2011, 114:1369-1379. [15] Colao A, Ferone D, Marzullo P, et al.Effect of different dopaminergic agents in the treatment of acromegaly[J] . Clin Endocrinol,1997, 82: 518-523 . [16] Cozzi R, Attanasio R, Lodrini S, et al.Cabergoline addition to depot somatostatin analogues in resistant acromegalicpatients:efficacy and lack of predictive value of prolactin status[J] . Clin Endocrinol, 2004, 61: 209-215. [17] Gatta B, Hau D, Catargi B, et al.Re-evaluation of the efficacy of the association of cabergoline to somatostatin analogues in acromegalicpatients[J] . Clin Endocrinol,2005, 63:477-478. [18] DiSarno A, Landi M L, Cappabianca P,et al.Resistance to cabergoline as compared with bromocriptine in hyperprolactinemia: prevalence, clinical definition, and therapeutic strategy[J] . Clin Endocrinol Metab,2001, 86:5256-5261. [19] Molitch M E.Pharmacologic resistance in prolactinomapatients[J] . Pituitary,2005,8:43-52. [20] Pascal V V, Weryha G, Bose M, et al.Hyperprolactinemic amenorrhea: treatment with cabergoline versus bromocriptine. Results of a national multicenter randomized double-blind study[J] . Presse Med,1995, 24:754-757. [21] Maurer R A.Estradiol regulates the transcription of the prolactin gene[J] . Biol Chem,1982, 257:2133-2136. [22] Lloyd G M, Meares J D, Jacobi J.Effects of oestrogen and bromocriptine on in vivo secretion and mitosis in prolactin cells[J] .Nature,1975, 255:497-498. [23] Pasqualini C, Bojda F, Kerdelhue’ B.Direct effect of estradiol on the number of dopamine receptors in the anterior pituitary of ovariectomizedrats[J] . Endocrinology,1986, 119:2484-2489. [24] Aoki M D, Aoki A, Maldonado C A.Sexual dimorphism of apoptosis in lactotrophs induced by bromocryptine[J] . Histochem Cell Biol,2001, 116:215-222. [25] Lamberts S W, Verleun T, Hofland L, et al.Differences in the interaction between dopamine and estradiol on prolactin release by cultured normal and tumorous human pituitary cells[J] .Clin Endocrinol Metab,1986, 63:1342-1347. [26] Molitch M E.Prolactinoma in pregnancy[J] . Best Pract Res Clin Endocrinol Metab,2011, 25:885-896. [27] Philippe C,Nicolas,Jovenin, et al.Treatment of pituitary adenomas by fractionated stereotactic radiotherapy:A prospective study of 110 patients[J] . Radiation Oncology Biol,2005, 62(2):333-341. [28] Shin M.Gamma knife mdiosurgery for pituitary adenoma[J] .Biomed Pharmacother,2002,56:178-181. [29] 张静华,李秀英,余小平,等.伽玛刀治疗术后残留垂体腺瘤[J] .立体定向和功能性神经外科杂志,2006,19(4):325-326. [30] Pollock B E,Nippoldt T B,Stafford S L, et al.Results of stereotactic radiosurgery in patients with hormone-producing pituitary adenomas:factors associated with endocrine normalization[J] .Natural,2002,97:525-530.