目的 评价不同的发病因素对武警部队士兵中轴型脊柱关节炎(axial spondyloarthritis,axSpA)的危险性。方法 选取2010-01至2017-06确诊为axSpA的士兵87例为研究对象,以同期在医院住院和门诊就诊的非风湿免疫性慢性关节疼痛患者102例为对照组,分析年龄、兵龄、职务、工作性质、家族史、吸烟史、遗传因素等多项内容与axSpA发病的关系。结果 对各种因素进行单因素Logistic回归分析后,年龄、吸烟史、工作性质、遗传背景与axSpA的发病有相关性,将上述因素纳入多因素Logistic回归模型分析,最后结果提示年龄、工作性质和遗传背景是axSpA发病的危险因素。结论 除强直性脊柱炎(ankylosing sponylitis,AS)患者外,部队有相当一部分放射学阴性中轴型脊柱关节炎(non-radiographic axSpA,nr-axSpA)患者。遗传因素是导致axSpA发病的绝对主导因素,工作性质亦与发病有关。
Abstract
Objective To investigate the factors associated with axSpA in soldiers of People's Armed Police Force.Methods Eighty-seven soldiers with axSpA were recruited between 2010 and 2017 while another 102 soldiers diagnosed with non-rheumatic chronic musculoskeletal pain during the same period were assigned as control group.Factors associated with axSpA, including age,length of military service,rank,types of work,history of the family,history of smoking and genetic factors, were analyzed in the study.Results The various factors were analyzed with chi-square and single factor logistic regression analysis.It was found that age,history of smoking,types of work and genetic backgrounds were statistically significant for the incidence of axSpA.Multivariate logistic regression analysis showed that age,types of work and genetic backgrounds were risk factors for axSpA.Conclusions In addition to AS,there is a considerable number of nr-axSpA patients in the Armed Police Force.The genetic background is a major risk factor for axSpA,and the types of work are closely related to the onset of axSpA.
关键词
部队 /
中轴型脊柱关节炎 /
危险因素
Key words
army force /
axial spondyloarthritis /
risk factors
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基金
黑龙江省自然科学基金资助项目(H2015002)
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