目的 评价加巴喷丁联合地氯雷他定治疗单纯性老年性瘙痒症的疗效及安全性。方法 选取2014-07至2017-04在门诊就诊的62例老年性瘙痒症患者,随机分为联合组和对照组,每组31例。联合组给予加巴喷丁联合地氯雷他定治疗,对照组单独给予地氯雷他定治疗,治疗8周后比较两组疗效、瘙痒、视觉模拟量表评分(VAS)、匹茨堡睡眠质量指数评分(PSQI)和不良反应。结果 联合组患者总有效率(70.97%)明显高于对照组患者的总有效率(41.94%),差异有统计学意义(P<0.05)。两组患者治疗前VAS评分及PSQI评分差异无统计学意义,治疗后VAS评分及PSQI评分均较治疗前明显下降,差异有统计学意义(P<0.05);组间对比,联合组患者治疗后VAS评分[(3.77±2.68)分]明显低于对照组患者评分[(5.10±1.99)分],差异有统计学意义(t=-2.207,P=0.031);联合组患者治疗后PSQI评分[(7.55±1.91)分]也明显低于对照组患者评分[(11.16±4.19)分],差异有统计学意义(t=-4.369,P=0.000)。两组均未发生严重不良反应。结论 加巴喷丁联合地氯雷他定治疗老年性瘙痒症可有效控制瘙痒症状,改善患者生活质量,不良反应少,为解除老年性瘙痒症患者的痛苦提供了一种行之有效的治疗手段。

Objective To evaluate the clinical efficacy and safety of gabapentin combined with desloratadine in the treatment of simple senile pruritus.Methods Sixty-two cases of senile pruritus patients were selected in our hospital between July 2014 and April 2017, who were randomly divided into the combination group and control group, with 31 cases in each.The combination group was treated with gabapentin combined with desloratadine while the control group was treated with desloratadine alone.After 8 weeks of treatment, the curative effect, pruritus visual analog scale score (VAS), Pittsburgh Sleep Quality Index (PSQI) and adverse reactions were compared between the two groups.Results After 8 weeks of treatment, the total effective rate of the combination group (70.97%) was significantly higher than that of the control group (41.94%), and the difference was statistically significant (P<0.05).There was no significant difference in the VAS score or PSQI score between the two groups before treatment.After treatment, the VAS score and PSQI score were significantly decreased, and the difference was statistically significant (P<0.05).The VAS score of the combination group after treatment was [(3.77±2.68) points], which was significantly lower than that of the control group [(5.10±1.99) points], so the difference was statistically significant (t=-2.207, P=0.031).After treatment, the PSQI score of the combination group [(7.55±1.91) points] was also significantly lower than that of the control group [(11.16±4.19) points], so the difference was statistically significant (t=-4.369, P=0.000). No serious adverse reactions occurred in either group.Conclusions Gabapentin combined with desloratadine in the treatment of senile pruritus can effectively control the symptoms of itching, improve the quality of life of patients, with fewer adverse reactions.