目的 探讨剂量对吡喹酮治疗青年慢性血吸虫病患者疗效的影响。方法 选取武警湖南总队医院2015-01至2016-12接诊的90例青年慢性血吸虫病患者,随机分为两组,各45例,低剂量组按40 mg/kg剂量服用吡喹酮,常规剂量组按60 mg/kg剂量服用,采用2 d疗法,2~3次/d,比较两组患者药物疗效。结果 低剂量组与常规剂量组疗效基本相当,治疗有效率分别为93.3%和95.65%,护肝药物使用率分别为24.4%和20.0%,不良反应发生率分别为44.4%和51.1%,差异均无统计学意义(P>0.05)。结论 低剂量吡喹酮和常规剂量吡喹酮疗效相当,可以选择40 mg/kg剂量用于治疗青年慢性血吸虫病者。
Abstract
Objective To explore the effect of doses on the efficacy of praziquantel in the treatment of chronic schistosomiasis.Methods Ninety patients treated at Hunan Corps Hospital of the Armed Police were randomly divided into two groups. In the low-dose group, 45 patients were given praziquantel at a dose of 40 mg/kg, while in the conventional-dose group the 45 patients were given a conventional dose of 60 mg/kg. Both groups took the drug two or three times a day for two days, two groups were compared.Results The efficacy of low-dose group and the conventional-dose group was roughly equal.The efficacy, usage of liver-protecting drugs, and adverse reaction rates were not significantly different between the two groups (P>0.05).Conclusions Low-dose praziquantel is as effective as conventional-dose praziquantel and can reduce the usage of praziquantel.
关键词
血吸虫病 /
吡喹酮 /
剂量 /
疗效 /
不良反应
Key words
schistosomiasis /
praziquantel /
dose /
efficacy /
adverse reactions
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参考文献
[1] 葛华阶, 白定华, 夏晓玲,等. 软肝丸治疗血吸虫病肝纤维化的效果[J]. 中国血吸虫病防治杂志, 2014, 26(2):197
[2] 吴维铎, 沈光金, 王 勇,等. 低剂量吡喹酮治疗慢性日本血吸虫病218例效果观察[J]. 热带病与寄生虫学, 2001, 30(2):79-80.
[3] 李剑珉, 徐 军, 涂永红. 小剂量吡喹酮治疗慢性血吸虫病的疗效观察[J]. 南昌大学学报(医学版), 2011, 51(6):33-33.
[4] Handing P, Desheng H, Ketai W. Approach to surveillance and consolidation during past 15 years after elimination of schistosomiasis in Shanghai[J]. Acta Trop, 2002, 82(2):301-303.
[5] 张利娟, 徐志敏, 钱颖骏,等. 2016年全国血吸虫病疫情通报[J]. 中国血吸虫病防治杂志, 2017,29(6):669-677.
[6] Salvadorrecatalà V, Greenberg R M. Calcium channels of schistosomes: unresolved questions and unexpected answers[J]. Wiley Interdisciplinary Reviews Membrane Transport & Signalling, 2012, 1(1):85-93.
[7] 欧阳青兰. 吡喹酮治疗血吸虫病的疗效及不良反应分析[J]. 临床合理用药杂志, 2016, 9(26):50-51.
[8] Cioli D, Pica-Mattoccia L. Praziquantel[J]. Parasitol Res, 2003, 90(1):S3-S9.
[9] 黄一心. 吡喹酮抗血吸虫作用机理的奥秘[J]. 中国血吸虫病防治杂志, 2010, 22(2):101-104.
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