目的 探讨矮身材儿童与正常儿童幽门螺杆菌(helicobacter pylori,H.pylori或Hp)感染率有无差别,总感染中的Ⅰ型Hp感染率有无差别,Hp感染是否与儿童身高生长相关。方法 选取民航总医院生长发育门诊就诊的矮身材儿童43例作为研究对象,其中男23例,女20例,年龄3～14岁,平均(6.77±3.08)岁。选取我院儿童保健门诊正常身高体检儿童56例为对照组,其中男29例,女27例,年龄3～14岁,平均(6.67±2.70)岁,测量身高、体重,记录出生体重、是否足月、是否母乳喂养、父母身高、是否偏食。留取血清-80 ℃冰箱保存,统一采用免疫印迹法检测血清抗Hp抗体并分型。结果 矮身材儿童Ⅰ型Hp感染率与对照组比较,有统计学差异;Ⅱ型Hp感染率及总感染率与对照组比较,无统计学差异。影响儿童身高的多因素回归分析,方程中变量有意义的是偏食。结论 虽然矮身材儿童Ⅰ型Hp感染率较正常儿童高,但感染Hp不是影响儿童身高生长的危险因素。
Abstract
Objective To investigate whether the Helicobacter pylori ( Hp)infection rate and that of HpⅠ are different between short stature and normal children and whether Hp infections are related to short stature.Methods Forty-three short stature children treated at our growth and development clinic were selected as subjects,including 23 boys and 20 girls aged 3 to 14,with an average age of (6.77±3.08).The control group consisted of children of normal height who visited our clinic for health checkups, including 29 boys and 27 girls aged 3 to 14,with an average age of (6.67±2.70) years .Their height and weight were measured,while data on birth weight, gestational age,breast feeding,parents’ height,and food preferences was collected,while serum samples were collected and stored in the -80 ℃ refrigerator before being analyzed for Hp antibody and classified.Results The HpⅠinfection rate was different between short stature and normal children. The total Hp and HpⅡinfection rates were not significantly different between the two groups. Multifactor logistic analysis of height showed that food preferences were of statistical significance.Conclusions Although the HpⅠinfection rate is different between short stature and normal children, the Hp infection rate is not associated with children’s height growth.
关键词
Ⅰ型幽门螺杆菌 /
儿童 /
生长迟缓
Key words
Helicobacter pyloriⅠ /
children /
growth retardation
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