目的 观察负荷量阿司匹林、氯吡格雷联合低分子肝素治疗短暂性脑缺血发作(aransient ischemic attack ,TIA)的临床疗效及安全性。方法 96例TIA患者随机分为对照组和观察组。对照组使用单剂量阿司匹林和氯吡格雷,观察组用负荷量阿司匹林、氯吡格雷联合腹壁皮下注射低分子肝素,治疗1周时进行两组临床疗效评价。结果 观察组的总有效率为91.67%,高于对照组的70.83%(P<0.01)。两组脑出血、消化道出血、牙龈出血、皮肤黏膜出血等不良反应差异无统计学意义(P>0.05)。结论 负荷量阿司匹林、氯吡格雷联合低分子肝素治疗TIA疗效显著,安全可靠。

Objective To investigate the short-term curative effect and safety of a loading dose of aspirin and clopidogrel and low molecular weight heparin(LMWH)on frequent transient ischemic attack (TIA) . Methods Ninety-six patients with TIA were randomly divided into two groups: the control group treated with aspirin and clopidogrel and treatment group treated with a loading dose of aspirin, clopidogrel and LMWH.The clinical effects were analyzed in both groups after one week.Results The total effective rate was 91.67% in the treatment group,which was highter than that in the control group (70.83%) (P<0.01, but there was no significant difference between the two groups in the incidence of intractable hemorrhage or gastrointestinal hemorrhage.There was also no significant difference in mucocutaneous hemorrhage or gingi-val hemorrhage between the two groups (P>0.05). Conclusions A loading dose of aspirin and clopidogrel and LMWH therapy is effective and safe for frequent TIA.