目的 探讨去甲斑蝥素片辅助治疗食管癌患者放化疗效果的影响。方法 选取2015-05至2017-02襄阳市中心医院肿瘤科收治的食管癌患者68例,按随机数字表法将患者分为对照组和观察组,每组34例。两组患者均采用相同的放化疗方案,观察组患者在放化疗同时使用去甲斑蝥素片,比较给药后两组患者的临床疗效和毒副反应发生率。结果 观察组患者临床疗效(总有效率85.29%)明显高于对照组(总有效率73.53%),差异有统计学意义(P<0.05);放射性食管炎发生率(47.06%)明显低于对照组(79.41%),差异有统计学意义(P<0.05);用药期间出现的不良反应均有骨髓抑制、消化系统反应和肝肾功能损伤,与对照组相比,观察组发生的白细胞减少、粒细胞减少和恶心呕吐方面较对照组明显减少,差异有统计学意义(P<0.05)。结论 去甲斑蝥素片在放化疗的食管癌患者中起到增效减毒的作用。
Abstract
Objective To study the clinical efficacy of norcantharidin for esophageal cancer patients undergoing radiotherapy and chemotherapy.Methods The clinical data on 68 patients with esophageal cancer treated between May 2015 and February 2017 at Xiangyang Central Hospital was analyzed. The patients were divided into control group and observation group by random number method. Both groups received the same radiotherapy and chemotherapy program, but patients in the observation group were additionally given norcantharidin. The clinical efficacy and safety were reviewed.Results The disease control rate in the observation group(85.29%) was higher than that in control group(73.53%), P<0.05. The incidence of radiation-induced esophagitis in the observation group(47.06%) was lower than that in the control group(79.41%), P<0.05. The dose-limiting toxicity included bone marrow suppression, gastrointestinal symptoms and the damaged liver and kidney function. The incidence of bone marrow suppression and gastrointestinal symptoms was lower than that in the control group, P<0.05.Conclusions Norcantharidin used for treatment of esophageal cancer along with radiotherapy and chemotherapy can enhance clinical efficacy and reduce toxicity.
关键词
去甲斑蝥素片 /
食管癌 /
放射性食管炎 /
不良反应
Key words
norcantharidin /
esophageal cancer /
radiation esophagitis /
adverse reactions
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