目的 探讨痛风性关节炎(gout arthritis,GA)与单纯性高尿酸血症(simple hyperuricemia,SHUA)在临床指标上的差异性。方法 选择2011-01至2017-08武警湖北总队医院住院的151例高尿酸血症(hyperuricemia,HUA)患者的临床资料进行了回顾性分析,以存在GA症状的43例为GA组,其他为SHUA的108例为SHUA组;比较GA组和SHUA组在年龄、性别、体重指数(BMI)、吸烟饮酒史、血压、血压异常率、空腹血糖(FPG)、血糖异常率、三酰甘油(TG)、胆固醇(CHOL)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、血肌酐(CR)、血尿酸(UA)、心脏左室缩短分数(Left ventricular shortening fraction,LVFS)、左室心脏射血分数(Left ventricular ejection fraction,LVEF)指标上的差异情况。结果 (1)两组在年龄、吸烟史、饮酒史、BMI方面比较,差异无统计学意义,但GA组中男性患者比例较SHUA组更高(P=0.01)。(2)与SHUA组相比较,GA组的血糖异常率、FPG水平、血压异常率、收缩压水平、TG水平更低,差异有统计学意义(P<0.05)。(3)GA组CR水平明显高于SHUA组,差异有统计学意义(P=0.001)。(4)两组UA水平无统计学差异。(5)GA组LVFS明显高于SHUA组,差异有统计学意义(P=0.024)),但两组LVEF比较无统计学差异。结论 在所有的HUA中,GA患者的临床指标较SHUA患者更优。
Abstract
Objective To investigate the difference of clinical indicators between patients with gout arthritis and those with simple hyperuricemia.Methods The clinical data of 151 patients with hyperuricemia treated in Hubei Provincial Corps Hospital of Chinese People's Armed Police Force between January 2011 and October 2017 was retrospectively analyzed.Forty-three of these patients were assigned the gout arthritis group(GA)and the rest to the simple hyperuricemia group(SHUA). The difference in age, sex, body mass index (BMI), smoking, alcohol consumption, rates of abnormal blood pressure, blood pressure (BP), fasting plasma glucose (FPG), rates of abnormal blood glucose, triglyceride (TG), cholesterol (CHOL), high-density lipoprotein (HDL), low density lipoprotein (LDL), serum creatinine (CR), serum uric acid (UA) ,left ventricular shortening rate (LVFS),and left ventricular ejection fraction (LVEF)was compared between the two groups.Results 1. There was no significant difference between the two groups in age, smoking history, drinking history or body mass index (P<0.05). However, the proportion of males was higher in the GA group, and the difference was significant(P=0.01).2. Compared with the SHUA group, rates of abnormal blood glucose levels,fasting glucose levels,rates of abnormal blood pressure,systolic blood pressure and the level of triglyceride in the GA group were significantly lower(P<0.05). while the diastolic blood pressure levels, cholesterol, high-density lipoprotein, and low density lipoprotein were not significantly different between the two groups(P>0.05). 3. The serum creatinine level of the GA group was significantly higher than that in the SHUA group, and the difference was significant(P=0.001). 4. The serum uric acid level in GA group was not significantly different from that in SHUA group(P=0.399). 5. In terms of the left ventricular shortening rate(LVFS), the GA group was significantly higher than the SHUA group (P=0.024), but there was no significant difference between the two groups in the left ventricular ejection fraction (P=0.059).Conclusions The clinical indicators of gout arthritis (GA)patients are better than those of patients with simple hyperuricemia(SHUA)alone in hyperuricemia.
关键词
单纯性高尿酸血症 /
高尿酸血症 /
临床指标 /
痛风 /
痛风性关节炎
Key words
simple hyperuricemia /
hyperuricemia /
clinical indicator /
gout /
gout arthritis
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