目的 探讨高压氧舱治疗新生儿缺氧缺血性脑病的临床效果。方法 2013-01至2017-02选择住院治疗的130例新生儿缺氧缺血性脑病作为研究对象,按照随机数字法分为对照组和观察组,每组65例,对照组给予常规对症支持治疗,观察组在对照组治疗的基础上给予高压氧舱治疗,两组都治疗观察3个月。结果 治疗后观察组与对照组的总有效率分别为98.5%和81.5%,观察组的总有效率高于对照组(P<0.05)。治疗后观察组与对照组的MMSE评分分别为(89.45±5.39)分和(78.20±6.14)分,都明显高于治疗前的(65.23±8.14)分和(65.11±7.89)分(P<0.05),治疗后观察组的MMSE评分明显高于对照组(P<0.05)。治疗后两组的血清肌酸激酶、乳酸脱氢酶及肌酸激酶同工酶含量都明显低于治疗前(P<0.05),治疗后观察组的各指标也明显低于对照组(P<0.05)。两组治疗后NOX2灰度比值和ROS较治疗前均显著降低,观察组治疗后NOX2灰度比值(0.37±0.06)显著低于对照组(0.42±0.09)(P<0.05),ROS(518.85±54.48)U/ml显著低于对照组(551.28±69.93)U/ml(P<0.05)。结论 高压氧舱治疗新生儿缺氧缺血性脑病能改善患儿的心肌功能,抑制氧化应激作用,从而提高治疗效果,促进认知功能的改善,有很好的应用价值。
Abstract
Objective To investigate the clinical effect of hyperbaric oxygen in the treatment of neonatal hypoxic ischemic encephalopathy.Methods Between January 2013 and February 2017, 130 cases of neonatal hypoxic ischemic encephalopathy were selected as subjects, who were randomly divided into control group and observation group with 65 cases in each. The control group was given routine symptomatic treatment, while the observation group was additionally given hyperbaric oxygen therapy. Both groups were observed for three months.Results After treatment, the total effective rates in the observation group and the control group were 98.5% and 81.5%, respectively.After treatment, the MMSE scores in the observation group and the control group were 89.45±5.39 points and 78.20±6.14 points, compared with 65.23±8.14 points and 65.11±7.89 points before treatment (P<0.05).The levels of serum CK, LDH and CK were significantly lower after treatment in the two groups (P<0.05), and the indexes in the observation group were significantly lower after treatment than those in the control group (P<0.05).The NOX2 gray ratio and ROS in the two groups were significantly lower after treatment.The NOX2 gray ratio (0.37±0.06) in the observation group was significantly lower after treatment than in the control group (0.42±0.09) (P<0.05). ROS (518.85±54.48) U/ml in the observation group was also significantly lower than in the control group (551.28±69.93) U/ml (P<0.05).Conclusions Hyperbaric oxygen, when used in the treatment of neonatal hypoxic ischemic encephalopathy, can improve myocardial function while inhibiting oxidative stress, thus improving the therapeutic effect and promoting cognitive function, so it has good applicability.
关键词
高压氧舱 /
新生儿缺氧缺血性脑病 /
心肌功能 /
氧化应激
Key words
hyperbaric oxygen /
neonatal hypoxic ischemic encephalopathy /
myocardial function /
oxidative stress
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