目的 探讨血液净化模式对维持性血液透析(maintaince hemodialysis,MHD)患者血同型半胱氨酸的清除效果。方法 120例患者随机分为血液透析组、血液透析滤过组、高通量透析组、高通量透析+血液灌流组,每组30人。治疗6个月后,分别测定各组同型半胱氨酸(Hcy)水平。结果 血液透析组Hcy没有变化,其他三组明显下降,其中高通量透析+血液灌流组最为显著,并且有统计学意义,P<0.05。结论 高通血液透析+血液灌流能显著降低尿毒症患者Hcy水平,防止心血管事件发生,提高生活质量。
Abstract
Objective To investigate the effect of different blood purification modes on homocysteine clearance in patients with maintenance hemodialysis (MHD).Methods A total of one hundred and twenty patients were randomly divided into hemodialysis group, hemodialysis filtration group, high-flux dialysis group, and high-flux dialysis + hemoperfusion group, with 30 patients in each group.Six months after treatment, homocysteine levels were measured in each group.Results The levels of Hcy remained unchanged in hemodialysis group, and decreased significantly in the other three groups, especially in high-flux hemodialysis + hemoperfusion group (P<0.05).Conclusions Hyperventilation and hemoperfusion can significantly reduce Hcy levels, prevent cardiovascular events and improve the quality of life in uremic patients.
关键词
尿毒症 /
血液透析 /
血液灌流 /
高同型半胱氨酸
Key words
uremia /
hemodialysis /
blood perfusion /
homocysteine
{{custom_sec.title}}
{{custom_sec.title}}
{{custom_sec.content}}
参考文献
[1] Lovcic V,Kes P,Reiner Z.Characteirstics of hyperhomocysteinemia in dialysis patients [J].Acta Med Croatica,2006,60(1):21-26.
[2] Cheung A K,Samak M J,Yan G.et al.Cardiac disease in maintenance hemodialysis patients resuit of the HEMO Study [J].Kidney Int,2004 65(6):2380-2389.
[3] 张淑艳,刘家宇,郭 勇.血液透析滤过对尿毒症患者血浆同型半胱氨酸及C反应蛋白的去除作用[J].内科急危重症杂志,2008,14(5):261-262.
[4] Errier N,Senecal L,Dupuy A M,et al.Association between novel indices of malnutrition complex syndrome and cardiobascular disease in hemodialysis patients[J].Hemodial Int,2005,9(2):159.
[5] 白光辉,巴应贵.高同型半胱氨酸与慢性肾衰竭患者心血管并发症的相关性[J].中华肾脏病杂志,2011,27(3):219-220.
[6] 李 涛,杨定平,冯爱桥.血液透析、血液透析滤过及连续性肾脏替代治疗对尿毒症毒素的清除作用及对动脉粥样硬化程度的影响 [J].中国医药导报,2014,11(27):12-16.
PDF(484 KB)
