目的 探讨中性粒细胞与淋巴细胞比值(neutrophil-to-lymphocyte ratio,NLR)对妊娠晚期B族链球菌(group B streptococcus,GBS)感染孕妇发生胎膜早破的影响。方法 收集2017年6-11月在医院就诊的114例GBS阳性者为研究对象,根据是否发生胎膜早破将其分为胎膜早破组(31例)和非胎膜早破组(83例)。比较两组孕妇NLR的差异。结果 胎膜早破组NLR值(中位数为4.10,四分位数间距3.34~4.78)高于非胎膜早破组NLR值(中位数为3.56,四分位数间距2.86~4.36),差异具有统计学意义(P=0.019)。多因素logistic分析显示,NLR是GBS孕妇发生胎膜早破的独立预后因素,高NLR值患者发生胎膜早破的风险是低NLR值患者的3.029倍(95%CI为1.203～7.632)(P=0.019)。结论 NLR是GBS阳性孕妇发生胎膜早破的独立预后因素,对于GBS感染的高NLR孕妇应加强管理,及早采取预防措施,预防胎膜早破的发生。
Abstract
Objective To investigate the effects of the neutrophil-to-lymphocyte ratio (NLR) on the occurrence of premature rupture of membranes of GBS women in the late trimester of pregnancy.Methods One hundred and fourteen pregnant women who had been hospitalized and detected as GBS positive carriers between June and November of 2017 in the Maternal and Child Health Hospital of Baoding were selected as subjects and classified into premature rupture of membrane group (31 cases) and non-premature rupture of membrane group (83 cases) based on the occurrence of premature rupture of membranes. The difference of the neutrophil-to-lymphocyte ratio (NLR) was compared between the two groups.Results NLR value of the premature rupture of membrane group (the median value was 4.10, and the quartile range was 3.34-4.78) was higher than that of the non-premature rupture of membrane group (the median value was 3.56, and the quartile range was 2.86-4.36), so the difference was of statistical significance(P=0.019).Multivariate logistic analysis showed that NLR was an independent prognostic factor for premature rupture of membrane for GBS pregnant women.Patients with higher values of NLR were 3.029 times as vulnerable to premature rupture of membrane as those with lower NLR values(CI of 95% of the patients ranged from 1.203 to 7.632; P=0.019).Conclusions NLR is an independent prognostic factor for premature rupture of membrane among GBS pregnant women. For those GBS pregnant women with higher NLR values, better care is needed, and early preventive measures should be taken to prevent premature rupture of membrane.
关键词
中性粒细胞与淋巴细胞比值 /
B族链球菌感染 /
胎膜早破
Key words
neutrophil-to-lymphocyte ratio /
group B streptococcus infection /
premature rupture of membrane
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