目的 探讨呼吸系统功能状态与E-选择素(E-selectin)、可溶性细胞间黏附分子1(soluble inteFAellular adhesion molecule-1, sICAM-1)、可溶性血管细胞黏附分子1(souble vascular cell adhesion molecule 1, sVCAM-1)的相关性。 方法 选取体检中心健康体检者216名,根据HRA系统检测的呼吸系统功能状态的结果,将研究对象分为呼吸功能正常组,呼吸功能轻度改变组,支气管、呼吸道炎性反应状态组三组,分别编号为A、B、C组。清晨空腹采血,留取血清,测定sICAM-1、sVCAM-1、E-selectin的含量。 结果 与A组相比,吸烟使B、C组呼吸系统功能状态改变的危险性增大(OR=1.216,95%CI:0.6~2.466;OR=3.2,95%CI:1.502~6.819)。随着呼吸系统功能状态炎性程度的增加,E-selectin、sICAM-1、sVCAM-1的浓度明显增高,且差异有统计学意义(P均＜0.01)。A组中E-selectin、sICAM-1、sVCAM-1的浓度在吸烟组和非吸烟组的差异均无统计学意义;B组中,与非吸烟组相比,吸烟组sICAM-1、sVCAM-1明显增高(P均<0.01);在C组中,吸烟组中E-selectin、sICAM-1、sVCAM-1明显高于非吸烟组,且差异均有统计学意义(P均＜0.01)。 结论 随着呼吸系统功能状态严重程度的增高,E-selectin、sICAM-1、sVCAM-1的浓度明显增高。吸烟者血清E-selectin、sICAM-1、sVCAM-1的水平增加。

Objective To explore the relationships between the functional status of the respiratory system and sICAM-1、sVCAM-1、E-selectin.Methods Two hundred and sixteen people who came to our center for physical examination were enrolled in this study. According to the functional status of the respiratory system assessed by the HRA system, these subjects were divided into the respiratory function normal group (group A), mild respiratory function group (group B), and the bronchial and respiratory inflammation group (group C). Fasting blood was collected in the early morning to obtain the serum for determination of levels of intercellular adhesion molecule 1 (sICAM-1), soluble vascular cell adhesion molecule 1 (sVCAM-1), and E - select element (E-selectin).Results (1)Compared with group A, smoking increased the risk of changes in the respiratory function status in group B and C (OR=1.216, 95% CI: 0.6-2.466, OR=3.2, 95%CI: 1.502-6.819). (2)With the increasing inflammation of the respiratory function status, the concentrations of E-selectin, sICAM-1 and sVCAM-1 significantly increased, and the difference was statistically significant (P<0.01). (3) In group A, the concentrations of E-selectin, sICAM-1 and sVCAM-1 were not significantly different between the smokers and non-smokers. In group B, the concentrations of sICAM-1 and sVCAM-1 were significantly higher among smokers than among non-smokers (P=0.437, 0.437, 0.000). In group C, the concentrations of E-selectin, sICAM-1 and sVCAM-1 were significantly higher among smokers than among non-smokers(P<0.01).Conclusions With the increasing severity of the respiratory function status, concentrations of E-selectin, sICAM-1 and sVCAM-1 are significantly increased. Levels of E-selectin, sICAM-1 and sVCAM-1 in smokers’ serum tend to increase.