目的 探讨糖尿病视网膜病变(diabetic retinopathy, DR)与超氧化物歧化酶(superoxide dismutase, SOD)活性值的关系。方法 选取2016-06到2018-02在眼科门诊诊断为DR的患者32例(DR组),患病时间12~25年。检测DR患者血清中SOD活性值并与10名健康人(对照组)进行比较。按国际DR分组标准,将32例DR分成背景期、轻度非增殖期与严重非增殖期,并对SOD活性值进行组间两两比较。结果 对照组血清中SOD活性值为(177.27±29.61)U/mg,DR组为(128.69±39.93)U/mg, DR组SOD活性值明显降低(P<0.01);DR背景期组为(144.68±40.05)U/mg,轻度非增殖期组为(128.41±28.01)U/mg,严重非增殖期组为(94.83±26.51)U/mg,DR背景期组和严重非增殖期组比较,差异有统计学意义(P<0.05)。结论 血清SOD活性值随DR病变的进展而逐渐降低,提示DR病变的发 生、发展与血清 SOD活性值下降有关 。
Abstract
Objective To study the relationships between superoxide dismutase (SOD) activity and diabetic retinopathy (DR).Methods After the approval by the hospital ethics committee and full notification of the patients, 32 cases of DR treated between June 2016 and February 2018 in the Department of Ophthalmology were randomly selected. The course of the diabetic disease ranged from 12 to 25 years. The activity of SOD in the serum of 32 patients with DR was detected and compared with 10 normal controls. According to the international DR grouping standard, these 32 DR patients were divided into the background DR group, mild non-proliferative DR group and severe non-proliferative DR group. The Results were compared between each two groups.Results The SOD activity in the normal control group was (177.27±29.61) U/mg, and (128.69±39.93) U/mg in DR patient group. The SOD activity in the DR group was significantly lower than that of control (P<0.01). The SOD activity in the background group was (144.68±40.05) U/mg, (128.41±28.01) U/mg in the mild non-proliferative DR group, and (94.83±26.51)U/mg in the severe non-proliferative DR group, so there was significant difference between the background group and the severe non-proliferative DR group (P<0.05).Conclusions The activity of serum SOD decreases with the development of DR, suggesting that the occurrence and development of DR are related to the decrease of SOD activity.
关键词
糖尿病视网膜病变 /
超氧化物歧化酶
Key words
superoxide dismutase /
diabetic retinopathy
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