目的 探讨醒脑静联合法舒地尔对急性缺血性脑梗死患者神经功能及血流动力学的影响。方法 选取医院2016-08至2018-08收治的急性缺血性脑梗死患者188例,按照随机数字表法分为对照组和研究组,每组94例,对照组采用常规治疗,研究组在此基础上联合醒脑静与法舒地尔治疗。比较两组患者临床疗效、治疗后血流动力学指标和不良反应发生率、治疗前后神经功能评分、相关因子水平及日常生活能力评分。结果 研究组治疗有效率较对照组明显升高,差异有统计学意义(P＜0.05);治疗后,两组患者美国国立卫生研究院卒中量表(national institute of health stroke scale,NIHSS)评分、日常生活能力量表(activities of daily living,ADL)评分、神经元特异性烯醇化酶(neuron-specific enolase,NSE)、S100β蛋白(S100β protein ,S100β)、脑源性神经营养因子(brain-derived neurotrophic factor ,BDNF)均明显优于治疗前(P＜0.05),研究组患者相关指标均明显优于对照组(P＜0.05);治疗后研究组基底动脉(basilar artery,BA)和大脑中动脉(middle cerebral artery,MCA)舒张期低值血流速度(diastolic flow velocity,Vd)、收缩期峰值血流速度(systolic blood flow velocity,Vs)和平均血流速度(average blood flow velocity,Vm)均明显高于对照组(P＜0.05);两组患者均未发生严重不良反应,不良反应发生率比较差异无统计学意义(P＞0.05)。结论 醒脑静联合法舒地尔对急性脑梗死具有较佳的临床疗效,不仅能有效改善患者血流动力学,同时还能促进神经功能恢复。
Abstract
Objective To explore the effect of Xingnaojing combined with fasudil on neurological function and hemodynamics in patients with acute ischemic cerebral infarction.Methods A total of 188 patients with acute ischemic cerebral infarction admitted to our hospital between August 2016 and August 2018 were divided into the control group and research group using the random number table method. Patients of the control group(94 cases)received routine treatment, while the study group(94 cases) was additionally given Xingnaojing and fasudil. The clinical efficacy, hemodynamic parameters and incidence of adverse reactions, neurological function scores, related factors and scores of activities of daily living before treatment were compared with those after treatment in both groups.Results The effective rate of treatment in the study group was significantly higher than that in the control group(P<0.05).After treatment, the NIHSS, ADL, NSE, S100 beta protein and brain-derived neurotrophic factor (BDNF) scores of the two groups became significantly better(P<0.05). After treatment, the diastolic low velocity (Vd), systolic peak velocity (Vs) and mean velocity (Vm) of the basilar artery (BA) and middle cerebral artery (MCA) in the study group were significantly higher than those in the control group(P<0.05),but there was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusions Xingnaojing combined with fasudil has a better clinical effect on acute cerebral infarction. It can not only effectively improve the hemodynamics of patients, but also promote the recovery of nerve function.
关键词
醒脑静 /
法舒地尔 /
急性缺血性脑梗死 /
神经功能 /
血流动力学
Key words
Xingnaojing /
fasudil /
acute ischemic cerebral infarction /
neurological function /
hemodynamics
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