目的 探讨斑蝥酸钠维生素B6注射液对乳腺癌辅助化疗患者血清白介素(interleukin,IL-6)、IL-17、肿瘤坏死因子-α(tumor necrosis factor,TNF-α)及巨噬细胞移动抑制因子(macrophage migration inhibitory factor,MIF)表达水平的影响。方法 选择2014-05至2018-06在医院诊治的中晚期乳腺癌患者122例作为研究对象,根据治疗方法不同分为研究组(62例)与对照组(60例)。对照组给予常规化疗,研究组在对照组治疗的基础上给予斑蝥酸钠维生素B6注射液治疗,两组都化疗观察4个周期,记录IL-6、IL-17、TNF-α及MIF表达水平的变化。结果 化疗后研究组的总有效率为67.7%,高于对照组的33.3%(P<0.05)。两组化疗期间的骨髓抑制、消化道反应、脱发、血小板下降等毒副反应发生情况对比,差异均无统计学意义。两组化疗后的血清IL-6、IL-17、TNF-α及MIF水平均低于化疗前(P<0.05),且研究组低于对照组(P<0.05)。研究组化疗后的CD3+、CD4+水平高于化疗前(P<0.05),也高于对照组(P<0.05),对照组化疗前后对比,差异无统计学意义。随访至2019-02,研究组的总生存期及无进展生存期都长于对照组(P<0.05)。结论 斑蝥酸钠维生素B6注射液在乳腺癌辅助化疗患者中的应用能抑制血清IL-6、IL-17、TNF-α及MIF的表达,改善患者的免疫功能,提高化疗效果,且不会增加毒副反应的发生,从而延长患者的生存时间。
Abstract
Objective To investigate the effects of sodium cantharidate and vitamin B6 injection on levels of serum interleukin (IL)-6, IL-17, tumor necrosis factor (TNF)-α and Macrophage migration inhibitory factor (MIF) in patients with breast cancer under adjuvant chemotherapy.Methods One hundred and twenty-two patients with advanced breast cancer who were treated between May 2014 and June 2018 were selected as subjects and divided into the study group(n=62) and the control group (n=60) according to treatment methods. The control group received conventional chemotherapy, while the study group was additionally given sodium cantharidate and vitamin B6 injection. The two groups were treated with chemotherapy for four cycles, and the expression levels of IL-6, IL-17, TNF-α and MIF were recorded.Results The total effective rate of the study group after chemotherapy was 67.7%, which was significantly higher than that of the control group (33.3%) (P<0.05). There was no significant difference in the incidence of such toxic side effects as myelosuppression, digestive tract reaction, alopecia or thrombocytopenia between the two groups. The levels of serum IL-6, IL-17, TNF-α and MIF in the two groups were significantly lower after chemotherapy (P<0.05), especially in the study group (P<0.05). The levels of CD3+ and CD4+ in the study group were significantly higher after chemotherapy (P<0.05), especially in the study group (P<0.05), but there was no significant change in the control group after chemotherapy. KM analysis showed that the overall survival and progression-free survival of the study group were significantly longer than those of the control group (P<0.05).Conclusions The application of sodium cantharidate and vitamin B6 injection in breast cancer adjuvant chemotherapy can inhibit the expressions of serum IL-6, IL-17, TNF-α and MIF, improve the immune function of patients and enhance the effect of chemotherapy The occurrence of toxic and side effects will not increase, thereby prolonging the survival of patients.
关键词
斑蝥酸钠维生素B6注射液 /
乳腺癌 /
化疗 /
白介素-6 /
巨噬细胞移动抑制因子
Key words
sodium cantharidate vitamin B6 injection /
breast cancer /
chemotherapy /
interleukin-6 /
macrophage migration inhibitory factor
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