目的 探讨308 nm准分子激光联合口服依巴斯汀等药物治疗玫瑰糠疹的效果。方法 选取2018-05至2019-04武警特色医学中心皮肤性病门诊符合诊断标准、患玫瑰糠疹的武警战士81例,采用随机数字表法分为治疗组与对照组,治疗组42例,对照组39例。治疗组采用308 nm激光联合口服依巴斯汀等治疗,对照组采用外用药联合依巴斯汀等药物治疗,比较两组的治疗效果及不良反应。结果 治疗组和对照组分别出现2例和1例红斑和色素沉着现象,差异无统计学意义。治疗组痊愈30例,显效9例,好转3例,无效0例,总有效率100.0%;对照组痊愈20例,显效6例,好转10例,无效3例,总有效率92.3%;治疗组痊愈率71.4%明显高于对照组的51.3%,两组对比差异有统计学意义(P<0.05),但总有效率差异无统计学意义。治疗组与对照组比较,瘙痒、丘疹、鳞屑、红斑症状缓解时间均明显缩短,差异有统计学意义(P<0.05)。结论 加用308 nm准分子激光治疗玫瑰糠疹治疗过程简单,缩短了症状缓解时间,值得推广。

Objective To investigate the therapeutic effect of 308 nm excimer laser combined with oral medicine against pityriasis rosea in Armed Police.Methods Eighty-one cases of pityriasis rosea from Armed Police who were treated at the skin clinic of our center between May 2018 and April 2019 were sampled as subjects according to the diagnostic criteria. These patients were divided into the treatment group and control group using the random number table method. The treatment group was treated with 308 nm laser combined with oral drug therapy, while the control group was treated with drugs for external use plus oral drugs. The curative effect and adverse reactions were compared between the two groups.Results There were 2 patients and 1 patient with erythema and pigmentation in the two groups respectively, and the difference was not statistically significant (P>0.05). In the treatment group, 42 cases were treated, 30 of whom were cured, 9 were effectively treated, and 3 were improved, so the total effective rate was 100.0%,compared with 39, 20, 6 and 10 in the control group, in which the total effective rate was 92.3%. According to the results of grade data, there was significant difference in the curative effect between the two groups (P<0.05), but there was no significant difference in the total effective rate. The difference in efficacy between the two groups was statistically significant (P<0.05). Symptom remission took less time in the experimental group than in the control group (P<0.05).Conclusions Pityriasis rosea is a common inflammatory skin disease with obvious clinical features, which seriously affects the work, life and training of Armed Police soldiers. 308 nm excimer laser treatment can effectively shorten the remission time of symptoms. Compared with the control group, such treatment process is simple, and it is not affected by training tasks,so it should be made more accessible to patients with pityriasis rosea in the army.