目的 观察地特胰岛素治疗妊娠糖尿病的临床疗效。方法 选取2016-06至2017-06武警内蒙古总队医院收治的88例妊娠糖尿病患者,随机分为2组,每组44例。对照组皮下注射优泌林N治疗,观察组皮下注射地特胰岛素,比较两组临床相关指标情况。结果 治疗2周后,观察组血糖达标率为79.55%(35/44),高于对照组59.09%(26/44),差异有统计学意义(P<0.05);观察组血糖达标时间[(9.33±1.74)d]比对照组短[(11.25±2.05)d],且胰岛素用量[(16.25±3.24)U]少于对照组[(26.35±7.54)U],差异均有统计学意义(P<0.05)。观察组治疗3个月后的FPG、HbA1c水平均比对照组低,差异均有统计学意义(P<0.05)。观察组妊娠结局明显优于对照组(P<0.05)。结论 妊娠糖尿病应用地特胰岛素治疗后,能有效控制血糖水平,并改善母婴结局,且低血糖发生率低,安全、有效。
Abstract
Objective To observe the clinical efficacy and related indicators of insulin detemir in the treatment of gestational diabetes mellitus.Methods The clinical data of 88 patients diagnosed with GDM between June 2016 and June 2017 was selected. According to options of treatment,these patients were divided into two groups, with 44 cases in each. The control group was treated with subcutaneous injection of Humulin N, while the observation group was subcutaneously injected with insulin detemir. The clinically relevant indicators were compared between the two groups.Results After 2 weeks of treatment, the blood glucose index and pregnancy outcome of the observation group were significantly better than those of the control group. The difference was statistically significant(P<0.05).Conclusion For patients with gestational diabetes mellitus, insulin detemir is safe and effective, which can help control their blood glucose levels, improve the maternal and infant outcomes and induce lower incidence of hypoglycemia.
关键词
地特胰岛素 /
妊娠糖尿病 /
血糖指标 /
母婴结局
Key words
insulin detemir /
gestational diabetes /
blood glucose index /
maternal and child outcomes
{{custom_sec.title}}
{{custom_sec.title}}
{{custom_sec.content}}
参考文献
[1] 曹会荣,郗小丽,梁媛哲.医学营养治疗对妊娠期糖尿病妊娠结局的影响[J].河北医药,2017,39(17):2678-2679.
[2] 张同美,李会荣.营养治疗对妊娠期糖尿病分娩结局及新生儿免疫功能影响[J].西南国防医药,2017,27(12):1346-1348.
[3] 中华医学会糖尿病学分会.中国2型糖尿病防治指南(2017年版)[J].中国实用内科杂志,2018,11(4):4-50.
[4] Hod M,Kapur A,Sacks D A,et al.The International Federation of Gynecology and Obstetrics (FIGO) Initiative on gestational diabetes mellitus: a pragmatic guide for diagnosis, management, and care[J].Int J Gynaecol Obstet,2015,131:S173.
[5] Koivusalo S B,Rönö K, Stachlempinen B, et al. Response to Comment on Koivusalo et al. Gestational Diabetes Mellitus Can Be Prevented by Lifestyle Intervention: The Finnish Gestational Diabetes Prevention Study (RADIEL): A Randomized Controlled Trial[J]. Diabetes Care,2016,39:24-30.
[6] 赖丽萍,凤香清,蒋凤秀,等.多次胰岛素注射与胰岛素泵治疗妊娠糖尿病的有效性及安全性比较[J].临床内科杂志, 2016,33(9):601-603.
[7] 刘宝红.胰岛素泵在糖尿病孕产妇中的应用效果研究[J].糖尿病新世界,2017,35(17):91-92.
[8] 王 平,赵 蕾,徐 锌,等.地特胰岛素联合利拉鲁肽治疗血糖控制不佳2型糖尿病患者的临床观察[J].中国糖尿病杂志,2015,23(6):524-526.
[9] 朱伟宏,袁月星.地特胰岛素治疗老年2型糖尿病疗效和安全性[J].中国循证心血管医学杂志,2016,8(7):840-842.
PDF(370 KB)
