目的 了解武警部队新兵HLA-B27阳性率情况,探讨其检测的意义。方法 使用流式细胞技术,检测武警某部430例新兵的HLA-B27抗原,并对其阳性率和地方人群进行比较。结果 430例样本中HLA-B27阳性23例,阳性率5.35%,和文献中安徽淮南市、河北邯郸市、四川达州市、广州市,以及福建泉州市的健康人群HLA-B27阳性率相比,差异无统计学意义(P＞0.05)。结论 检测入伍新兵HLA-B27,观察长期的军事训练是否更容易诱发HLA-B27阳性者患强直性脊柱炎,有助于减少部队非战斗损伤,提高部队战斗力。
Abstract
Objective To investigate the significance of testing HLA-B27 in army recruits.Methods HLA-B27 antigen was detected in 430 recruits of Armed Police Force using flow cytometry. The positive rate was compared with that of the local populations.Results Flow cytometry detection showed that there were 23 positive cases in the 430 recruits, with a positive rate of 5.35%. Compared with healthy populations in Huainan of Anhui, Handan of Hebei, Dazhou of Sichuan, Guangzhou of Guangdong, and Quanzhou of Fujian, the positive rate was not significantly different (P>0.05).Conclusion Detection of HLA-B27 antigen in recruits and observing whether military training is more likely to induce ankylosing spondylitis in HLA-B27 positive soldiers will help reduce non-combat injuries and enhance the combat effectiveness of troops.
关键词
新兵 /
HLA-B27 /
强直性脊柱炎
Key words
recruits /
HLA-B27 /
ankylosing spondylitis
{{custom_sec.title}}
{{custom_sec.title}}
{{custom_sec.content}}
参考文献
[1] Brewerton D A, Hart F D, Nicholls A, et al. Ankylosing spondylitis and HL-A 27[J].Lancet,1973,1(7809):904-907.
[2] Schlosstein L, Terasaki P I, Bluestone R, et al. High association of an HL-A antigen, W27 with ankylosing spondylitis[J]. N Engl J Med,1973,288(14):704-706.
[3] 李 维,府伟灵.强直性脊柱炎与HLA-B27[J].国外医学:临床生物化学与检验学分册,2002,23(5):295-298.
[4] 宋加永.HLA-B27检测在强直性脊柱炎临床诊断价值分析[J].世界最新医学信息文摘,2015,15(3):115-121.
[5] 张小芳,张云刚,李守霞,等.HLA-B27与强直性脊柱炎的相关性研究[J].中国现代医学杂志,2013,23(36):56-59.
[6] 吴 娟.检测强直性脊柱炎患者人类白细胞抗原B27的临床意义[J].检验医学与临床,2013,10(6):663-665.
[7] 蒋 娟,熊小敏,张卫云,等. 人类白细胞抗原B27在强直性脊柱炎的临床意义[J].生物技术通讯,2014,25(3):410-411.
[8] 卢海景,饶华春,郭庆昕,等. 人类白细胞抗原-B27与强直性脊柱炎的相关性分析[J]. 检验医学与临床,2011,8(17):2132-2133.
[9] 白世杰,托 娅,张保平,等.流式细胞术与 PCR-SSP 法检测 HLA-B27的比对及 HLA-B27亚型的研究[J].检验医学与临床,2016,13(5):586-587.
[10] 洪 俊,饶永彩.流式HLA-B27测定法在强直性脊椎炎诊断中的临床价值[J].职业与健康,2012,28(6):693-695.
[11] 韩仁芳,陈梦雅,刘 瑞,等.强直性脊柱炎2261例流行特征及功能状态现状分析[J].安徽医药,2017,21(1):73-77.
[12] 贾连玲,王欣茹,白 静,等.强直性脊柱炎患者HLA-B27抗原、ESR、CRP等检测指标水平分析及临床意义[J].国际检验医学杂志,2018,39(2):243-245.
[13] 周萍丽.早期强直性脊柱炎骶髂关节病变应用X线、CT和MRI的诊断价值研究[J].中国CT和MRI杂志,2016,14(10):117-120.
基金
武警总医院院级课题-临床类推广应用(WZ2017028)
PDF(514 KB)
