[1] Kang R, Lotze M T, Zeh H J, et al. Cell death and DAMPs in acute pancreatitis[J]. Mol Med, 2014, 20: 466-477.
[2] Silk E, Zhao H, Weng H, et al. The role of extracellular histone in organ injury[J]. Cell Death Dis, 2017, 8(5): e2812.
[3] 王力军,王镜媛,郭 菲,等. NETs与脓毒症及其凝血功能障碍研究新进展[J]. 医学综述,2018,24(21):4182-4185,4191.
[4] Ham A, Rabadi M, Kim M, et al. Peptidyl arginine deiminase-4 activation exacerbates kidney ischemia-reperfusion injury[J]. Am J Physiol Renal Physiol, 2014, 307(9): F1052-1062.
[5] McDonald B, Davis R P, Kim S J, et al. Platelets and neutrophil extracellular traps collaborate to promote intravascular coagulation during sepsis in mice[J]. Blood, 2017, 129(10):1357-1367.
[6] Chaaban H, Keshari R S, Silasi-Mansat R, et al. Inter-α inhibitor protein and its associated glycosaminoglycans protect against histone-induced injury[J]. Blood, 2015, 125(14):2286-2296.
[7] Hoppenbrouwers T, Autar A S A, Sultan A R, et al. In vitro induction of NETosis: comprehensive live imaging comparison and systematic review[J]. PLoS One, 2017, 12(5): e0176472.
[8] Bosmann M, Grailer J J, Ruemmler R, et al. Extracellular histones are essential effectors of C5aR- and C5L2-mediated tissue damage and inflammation in acute lung injury[J]. FASEB J, 2013, 27(12):5010-5921.
[9] Clark S R, Ma A C, Tavener S A, et al. Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood[J]. Nat Med, 2007, 13(4): 463-469.
[10] Xu J, Zhang X, Monestier M, et al. Extracellular histones are mediators of death through TLR2 and TLR4 in mouse fatal liver injury[J]. J Immunol, 2011, 187: 2626-2631.
[11] Wen Z, Liu Y, Li F, et al. Circulating histones exacerbate inflammation in mice with acute liver failure[J]. J Cell Biochem, 2013, 114: 2384-2391.
[12] Bamboat Z M, Balachandran V P, Ocuin L M, et al. Toll-like receptor 9 inhibition confers protection from liver ischemia-reperfusion injury [J]. Hepatology, 2010, 51(2): 621-632.
[13] Huang H, Evankovich J, Yan W, et al. Endogenous histones function as alarmins in sterile inflammatory liver injury through Toll-like receptor 9 in mice[J]. Hepatology, 2011, 54: 999-1008.
[14] Huang H, Chen H W, Evankovich J, et al. Histones activate the NLRP3 inflammasome in Kupffer cells during sterile inflammatory liver injury[J]. J Immunol, 2013, 191: 2665-2679.
[15] Pereira L F, Marco F M, Boimorto R, et al. Histones interact with anionic phospholipids with high avidity; its relevance for the binding of histone-antihistone immune complexes[J]. Clin Exp Immunol, 1994, 97(2):175-180.
[16] Abrams S T, Zhang N, Manson J, et al. Circulating histones are mediators of trauma-associated lung injury[J]. Am J Respir Crit Care Med, 2013, 187(2): 160-169.
[17] Abrams S T, Zhang N, Dart C, et al. Human CRP defends against the toxicity of circulating histones[J]. J Immunol, 2013, 191(5): 2495-2502.
[18] De Meyer S F, Suidan G L, Fuchs T A, et al. Extracellular chromatin is an important mediator of ischemic stroke in mice[J]. Arterioscler Thromb Vasc Biol, 2012, 32(8): 1884-1891.
[19] Fuchs T A, Bhandari A A, Wagner D D. Histones induce rapid and profound thrombocytopenia in mice[J]. Blood, 2011, 118(13): 3708-3714.
[20] Bolton S J, Russelakis-Carneiro M, Betmouni S, et al. Non-nuclear histone H1 is upregulated in neurones and astrocytes in prion and Alzheimer's diseases but not in acute neurodegeneration[J]. Neuropathol Appl Neurobiol, 1999, 25(5): 425-432.
[21] Gilthorpe J D, Oozeer F, Nash J, et al. Extracellular histone H1 is neurotoxic and drives a pro-inflammatory response in microglia[J]. F1000Res, 2013, 2:148.
[22] Vogel B, Shinagawa H, Hofmann U, et al. Acute DNase1 treatment improves left ventricular remodeling after myocardial infarction by disruption of free chromatin[J]. Basic Res Cardiol, 2015, 110: 15.
[23] 王力军,寿松涛,柴艳芬,等. 胞外组蛋白在脓毒症及其心肌抑制机制研究新进展[J]. 中华急诊医学杂志,2018, 27(1):111-114.
[24] Caudrillier A, Kessenbrock K, Gilliss B M, et al. Platelets induce neutrophil extracellular traps in transfusion-related acute lung injury[J]. J Clin Invest, 2012,122(7):2661-2671.
[25] Luger K, Mäder A W, Richmond R K, et al. Crystal structure of the nucleosome core particle at 2.8 A resolution[J]. Nature, 1997, 389(6648):251-260.
[26] Huang H, Tohme S, Al-Khafaji A B, et al. Damage-associated molecular pattern-activated neutrophil extracellular trap exacerbates sterile inflammatory liver injury[J]. Hepatology, 2015, 62(2): 600-614.
[27] Rosin D L, Okusa M D. Dying cells and extracellular histones in AKI: beyond a NET effect? [J]. J Am Soc Nephrol, 2012, 23(8):1275-1277.
[28] Wu H, Chen G, Wyburn K R, et al. TLR4 activation mediates kidney ischemia/reperfusion injury[J]. J Clin Invest, 2007, 117(10):2847-2859.
[29] Kang R, Zhang Q, Hou W, et al. Intracellular Hmgb1 inhibits inflammatory nucleosome release and limits acute pancreatitis in mice[J]. Gastroenterology, 2014, 146(4): 1097-1107.
[30] Chen R, Kang R, Fan X G, et al. Release and activity of histone in diseases[J]. Cell Death Dis, 2014, 5:e1370.
[31] Ekaney M L, Otto G P, Sossdorf M, et al. Impact of plasma histones in human sepsis and their contribution to cellular injury and inflammation[J]. Crit Care, 2014, 18: 543.
[32] Johansson P I, Windelv N A, Rasmussen L S, et al. Blood levels of histone-complexed DNA fragments are associated with coagulopathy, inflammation and endothelial damage early after trauma[J]. J Emerg Trauma Shock, 2013, 6: 171-175.
[33] Kawai C, Kotani H, Miyao M, et al. Circulating extracellular histones are clinically relevant mediators of multiple organ injury[J]. Am J Pathol, 2016, 186: 829-843.