目的 探讨年龄对轻度认知障碍(mild cognitive impairment,MCI)患者蒙特利尔认知评估量表基本版(the Montreal cognitive assessment-basic, MoCA-B)得分的影响。方法 选取2017年1－12月首都医科大学附属复兴医院神经内科门诊、住院患者及周边社区居民,诊断为MCI者190例,根据受试者年龄,分为3组:50~59岁(47例),60~69岁(73例),70~79岁(70例)。完成简易精神状态量表(Mini-Mental State Examination, MMSE)和MoCA-B。结果 3组MCI的性别、受教育程度、MMSE得分、MoCA-B总分均无统计学差异。MoCA-B的各亚项得分比较上,词语流畅性、延迟回忆在3组间差异有统计学意义(P<0.05)。60岁以下词语流畅性得分(0.8±0.5)略高于60岁以上组(0.5±0.6),但因平均分均在1分以内,差异无统计学意义。词语延迟回忆得分方面,60~69岁组(0.4±0.8)和70~79岁组(0.5±1.0)得分均明显低于50~59岁组(1.1±1.0),差异均有统计学意义(P<0.05)。结论 临床在动态观察MoCA-B总分变化的同时,还应注意一些认知域亚项的结果可能与年龄相关,特别是词语延迟回忆部分。
Abstract
Objective To investigate the difference in the Montreal Cognitive Assessment-Basic(MoCA-B) sub-item scores between patients of different age with mild cognitive impairment(MCI).Methods One hundred and ninety MCI patients were recruited from the outpatients and inpatients of the Department of Neurology and surrounding communities between January 2017 and December 2017. Patients were divided into three groups according to their age: 50-59(n=47), 60-69(n=73) and 70-79(n=70). All the patients were subjected to a survey by means of Mini-Mental State Examination(MMSE)and MoCA-B.Results There was no significant difference between the three groups in gender, levels of education, MMSE or MoCA-B. When each item of MoCA-B was compared between the three groups, verbal fluency test(VFT) and delayed recall were significantly different(P<0.05). Patients under 60 got a little higher scores in VFT than those above 60(0.8±0.5 vs 0.5±0.6), but the difference was not statistically significant. For verbal delayed recall, the scores of the three groups were(1.1±1.0),(0.4±0.8) and(0.5±1.0),respectively. Patients under 60 got higher scores than older ones. The difference was significant between the three groups(P<0.05).Conclusions When interpreting the scores of each item of MoCA-B, we should pay attention to the possible influence of age, especially the verbal delayed recall score.
关键词
轻度认知障碍 /
蒙特利尔认知评估量表 /
老化 /
认知评估 /
记忆
Key words
mild cognitive impairment /
Montreal Cognitive Assessment /
aging /
cognitive evaluation /
memory
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