目的 研究老年高血压患者颈动脉粥样硬化程度、血清中的脂联素、抵抗素水平的相关性。方法 选择2016-01至2017-12解放军总医院第三医学中心收治的老年高血压患者112例,所有患者均行颈部血管超声检查,根据颈动脉内中膜厚度将所有患者分为正常组32例,内中膜增厚组42例和斑块组38例,测定各组患者血清脂联素、抵抗素水平,之后进行对比分析及相关分析。结果 血清脂联素水平和颈动脉内中膜厚度呈负相关(r=-0.562),抵抗素水平和颈动脉内中膜厚度呈正相关(r=0.621),胰岛素抵抗、血清抵抗素水平是颈动脉粥样硬化的独立危险因素,血清脂联素水平是动脉粥样硬化的保护因素。结论 对于老年高血压患者早期监测脂联素和抵抗素水平的变化有助于监测颈动脉粥样硬化的发生发展。
Abstract
Objective To study the relationships between carotid atherosclerosis and levels of serum adiponectin and resistin in elderly patients with hypertension.Methods Correlation analysis was performed on 112 elderly patients with hypertension treated in our hospital between January 2016 and December 2017. All the patients underwent carotid artery ultrasound. According to the ultrasound results, these patients were divided into the normal group (32 cases), thickness group (42 cases) and atherosclerotic plaque group (38 cases). Serum adiponectin and resistin levels in each group were measured and compared.Results Serum adiponectin levels were negatively correlated with intima-media thickness(r=-0.562), while serum resistin levels were positively correlated(r=0.621). Insulin resistance and serum resistin levels were independent risk factors for carotid atherosclerosis, while serum adiponectin levels were protective factors for atherosclerosis.Conclusions Elderly patients with hypertension who have low serum adiponectin and high resistin levels are at higher risk of carotid atherosclerosis. For elderly patients with hypertension, monitoring serum adiponectin and resistin levels can help control carotid atherosclerosis.
关键词
老年高血压 /
颈动脉粥样硬化 /
脂联素 /
抵抗素
Key words
senile hypertension /
atherosclerosis /
adiponectin /
resistin
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