目的 探讨罗红霉素、地红霉素对寒区部队慢性鼻窦炎的治疗价值。方法 选择2016-09至2019-04寒区部队慢性鼻窦炎患者68例,根据用药方法分组,对照组以罗红霉素治疗,观察组以地红霉素治疗,比较两组治疗效果。结果 观察组治疗总有效率91.18%,对照组总有效率85.29%。观察组不良反应发生率11.11%,对照组不良反应发生率2.78%,两组之间无统计学差异(P>0.05),治疗后观察组鼻塞、头面部不适、嗅觉障碍等主观症状评分及鼻窦CT评分均明显低于对照组(P＜0.05)。结论 与罗红霉素相比,地红霉素可促使寒区部队慢性鼻窦炎患者症状显著改善,用药更为方便,且用药安全性高。

Objective To analyze the therapeutic effect of roxithromycin and dirithromycin against chronic sinusitis in cold regions.Methods Sixty-eight patients with chronic sinusitis in cold regions were divided according to the Methods of medication. The control group was treated with roxithromycin while the observation group was treated with erythromycin. The therapeutic effects of the two groups were compared.Results The total effective rate in the observation group and control group was 91.8% and 85.29% respectively. The rate of adverse reactions in the observation group and control group was 11.11% and 2.78% respectively. There was no significant difference between the two groups(P>0.05) .After treatment, the subjective symptom scores and sinus CT scores of nasal obstruction, head and face discomfort, olfactory disturbance in the observation group were significantly lower than those of the control group (P<0.05).Conclusions Compared with roxithromycin, dirithromycin can significantly improve the symptoms of patients with chronic sinusitis in cold regions, and it is more user-friendly and safer.