[1] Wang C, Xu J, Yang L, et al. Prevalence and risk factors of chronic obstructive pulmonary disease in China (the China Pulmonary Health[CPH]study): a national cross-sectional study[J].Lancet, 2018, 391(10131):1706-1717. [2] Ahmad Hassali M A, Muhammad S A, Shah S, et al. The economic burden of chronic obstructive pulmonary disease (COPD) in the USA, Europe, and Asia: results from a systematic review of the literature[J]. Expert Rev Pharmacoecon Outcomes Res, 2019, 18: 1-12. [3] Zhu B, Wang Y, Ming, J, et al. Disease burden of COPD in China: a systematic review[J]. Int J Chron Obstruct Pulmon Dis, 2018,13:1353-1364. [4] Spruit M A, Singh S J, Garvey C, et al. An official American Thoracic Society/European Respiratory Society statement: key concepts and advances in pulmonary rehabilitation[J]. Am J Respir Crit Care Med, 2013,188(8): e13-e64. [5] GOLD. 2020 Global strategy for prevention, diagnosis, management of chronic obstructive lung disease[EB/OL]. (2019-11-05). https://goldcopd.org/gold-reports/. [6] 王凤燕,王凌伟,杨宇琼,等.慢性阻塞性肺疾病年度研究进展[J].中华结核和呼吸杂志, 2019, 42(11): 858-861. [7] 陈亚红.2020年GOLD慢性阻塞性肺疾病诊断、治疗及预防全球策略解读[J].中国医学前沿杂志, 2019,11(12): 32-50. [8] Bolton C E, Singh S J, Walker P P, et al. Commentary: the British Thoracic Society guideline on pulmonary rehabilitation in adults[J]. Thorax, 2013, 68(9): 887-888. [9] Ries A L,Bauldoff G S, Carlin B W, et al. Pulmonary rehabilitation: joint ACCP/AACVPR evidence-based clinical practice guidelines[J]. Chest, 2007, 131(5 Suppl): 4S-42S. [10] 呼吸系统疾病基层诊疗指南专家组. 慢性阻塞性肺疾病基层诊疗指南(2018年)[J].中华全科医师杂志, 2018,17(ll): 856-870. [11] Alison J A, McKeough Z J, Johnston K, et al. Australian and New Zealand pulmonary rehabilitation guidelines [J]. Respirology, 2017, 22(4): 800-819. [12] 赵红梅.肺康复治疗在慢性阻塞性肺疾病治疗中的作用[J].中国临床医生杂志, 2017, 45(9): 8-11. [13] Porszasz J,Emtner M,Goto S,et al. Exercise training decreases ventilatory requirements and exercise-induced hyperinflation at submaximal intensities in patients with COPD[J]. Chest, 2005, 128(4): 2025-2034. [14] Richardson R S, Sheldon J, Poole D C, et al. Evidence of skeletal muscle metabolic reserve during whole body exercise in patients with chronic obstructive pulmonary disease [J].Am J Respir Crit Care Med, 1999, 159(3): 881-885. [15] Chen R, Chen X, Chen L, et al. Effect of endurance training on expiratory flow limitation and dynamic hyperinflation in patients withstable chronic obstructive pulmonary disease [J]. Intern Med J, 2014, 4(8):791-800. [16] Nasis I, Kortianou E, Vasilopoulou M, et al. Hemodynamic effects of high intensity interval training in COPD patients exhibiting exercise-induced dynamic hyperinflation[J]. Respir Physiol Neurobiol,2015, 217(10):8-16. [17] Zucker I H, Musch T I. Benefits of exercise training on cardiovascular dysfunction: molecular and integrative [J]. Am J Physiol Heart Circ Physiol, 2018, 315(4): H1027-H1031. [18] Ruegsegger G N, Booth F W. Health benefits of exercise[J].Cold Spring Harb Perspect Med, 2018, 8(7): 1-16. [19] Evans R A, Kaplovitch E, Beauchamp M K, et al. Is quadriceps endurance reduced in copd? A systematic review[J]. Chest, 2015, 147(3): 673-684. [20] Seymour J M, Spruit M A, Hopkinson N S, et al. The prevalence of quadriceps weakness in COPD and the relationship with disease severity[J]. Eur Respir J, 2010(36): 81-87. [21] Marklund S, Bui K L, Nyberg A, et al. Measuring and monitoring skeletal muscle function in COPD: current perspective [J]. Int J Chron Obstruct Pulmon Dis, 2019, 14: 1825-1838. [22] Vogiatzis I, Terzis G, Stratakos G, et al. Effect of pulmonary rehabilitation on peripheral muscle fiber remodeling in patients with COPD in GOLD stages Ⅱ to Ⅳ [J]. Chest, 2011, 140(3): 744-752. [23] Munari A B, Venâncio R S, Klein S R, et al. Physiological responses to the 6-min step test in patients with chronic obstructive pulmonary disease[J]. J Cardiopulm Rehabil Prev, 2020, 40(1): 55-61. [24] Desveaux L, Janaudis-Ferreira T, Goldstein R, et al. An international comparison of pulmonary rehabilitation: a systematic review [J]. COPD, 2015, 12(2):144-153. [25] Lavoie K L, Sedeno M, Hamilton A, et al. Behavioural interventions targeting physical activity improve psychocognitive outcomes in COPD [J]. ERJ Open Res,2019, 5(4): 00013-2019. [26] Nolan C M,Rochester C L. Exercise training modalities for people with chronic obstructive pulmonary disease[J]. COPD, 2019, 16(5-6): 378-389. [27] Meyer A, Zoll J, Charle s L A, et al. Skeletal muscle mitochondrial dysfunction during chronic obstructive pulmonary disease: central actor and therapeutic target [J]. Exp Physiol, 2013, 98(6): 1063-1078. [28] Rao V, Prem V. Effect of upper limb, lower limb and combined training on health-related quality of life in COPD[J]. Lung India, 2010, 27(1):4-7. [29] Panton L, Golden J, Broeder C, et al. The effects of resistance training on functional outcomes in patients with chronic obstructive pulmonary disease [J]. Eur J Appl Physiol, 2004, 91(4): 443-449. [30] Corbellini C, Boussuges A, Villafañe J H, et al. Diaphragmatic mobility loss in subjects with moderate to very severe COPD may improve after in-patient pulmonary rehabilitation[J]. Respir Care, 2018, 63(10): 1271-1280. [31] Neves L F, Reis M H, Plentz R D, et al. Expiratory and expiratory plus inspiratory muscle training improves respiratory muscle strength in subjects with COPD: systematic review[J]. Respir Care, 2014,59(9):1381-1388. [32] Benzo R, McEvoy C. Effect of health coaching delivered by a respiratory therapist or nurse on self-Management abilities in severe COPD: analysis of a large randomized study [J].Respir Care, 2019, 64(9):1065-1072. [33] Boutou A K, Tanner R J, Lord V M, et al. An evaluation of factors associated with completion and benefit from pulmonary rehabilitation in COPD [J]. BMJ Open Respir Res, 2014, 1(1): e000051. [34] Pehlivan E, Yazar E, Balcι A, et al. Comparison of compliance rates and treatment efficiency in home-based with hospital-based pulmonary rehabilitation in COPD[J]. Turk Thorac J, 2019, 20(3):192-197. [35] Robinson S A, Shimada S L, Quigley K S. A web-based physical activity intervention benefits persons with low self-efficacy in COPD: results from a randomized controlled trial [J]. J Behav Med, 2019, 42(6):1082-1090. [36] Gimigliano F, Negrini S. The World Health Organization “Rehabilitation 2030: a call for action”[J]. Eur J Phys Rehabil Med, 2017, 53(2):155-168.