目的 探讨乌灵胶囊联合参松养心胶囊治疗老年心律失常伴失眠的临床疗效。方法 选取2018-10至2019-10门诊就诊的86例心律失常伴失眠的老年患者,随机分为对照组和观察组,每组43例。对照组常规治疗并加服参松养心胶囊;观察组在对照组的治疗基础上联合应用乌灵胶囊,两组均连续治疗6个月。比较两组治疗30 d临床疗效,治疗前、治疗30 d、3个月、6个月的匹兹堡睡眠质量指数量表(pittsburgh sleep quality index,PSQI)评分及临床总体印象量表 (clinical global impression scale,CGI) 评分变化、心功能改善情况。结果 观察组治疗总有效率97.67%,明显高于对照组(81.39%),差异有统计学意义(P<0.05);两组治疗30 d后 PSQI、CGI-S & CGI-I评分均较治疗前降低,差异有统计学意义(P<0.05),且观察组明显低于对照组,差异有统计学意义(P<0.05)。两组治疗3、6个月 CGI评分,虽均有改善,但无统计学差异。观察组治疗6个月PSQI评分(7.05±0.63)与治疗30 d比较,下降明显(P<0.05),也明显低于对照组,差异有统计学意义(P<0.05)。两组均无明显不良反应。结论 乌灵胶囊联合参松养心胶囊对治疗老年患者心律失常伴失眠疗效确切,不良反应少。
Abstract
Objective To observe the clinical effects of Wuling capsules combined with Shensong Yangxin capsules against senile arrhythmia complicated with insomnia.Methods Eighty-six elderly patients with arrhythmia and insomnia treated at our clinic between October 2018 and October 2019 were randomly divided into the control group (CG) and observation group (OG),with 43 cases in each.Patients in the CG group were given Shensong Yangxin capsules (4 capsules per time,tid) in addition to conventional treatment,while those in the OG group additionally took Wuling capsules (3 capsules per time,tid).The course of treatment lasted 30 days.The clinical efficacy,PSQI score,CGI score and the extent to which cardiac function was improved were compared between the two groups.Results The effective rate of OG was 97.67%,compared with 81.39% in CG,so the difference was statistically significant (P<0.05).After treatment,the PSQI scores were significantly lower in both groups,especially in OG,and the difference was also statistically significant (P<0.05).The CGI scores of both groups decreased after thirty days of treatment,but the difference was not statistically significant.Heart rate (HR),PR interval and QTc interval in OG were improved more significantly than in CG.There were no adverse reactions in either group.Conclusions Itis clear that Wuling capsules combined with Shensong Yangxin capsules have good clinical effect against arrhythmia complicated with insomnia by improving sleep quality,cardiac function,and the quality of life in senile patients.
关键词
乌灵胶囊 /
参松养心胶囊 /
心律失常 /
失眠
Key words
wuling capsules /
shensong yangxin capsules /
arrhythmia /
isomina
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