目的 探讨不同内膜准备方案对整倍体单胚胎解冻移植妊娠结局的影响。方法 选取2015-11至2019-07行胚胎植入前遗传学非整倍体筛查(PGT-A)后行解冻移植的436例患者为研究对象。根据内膜准备方法不同分为两组:人工周期(HRT)组及自然周期(NC)组,比较两组患者的一般资料及妊娠结局。结果 两组年龄、子宫内膜厚度及PGT-A适应证分布比较,差异无统计学意义。两组间的HCG阳性率、临床妊娠率、流产率、活产率比较差异无统计学意义。结论 整倍体单胚胎解冻移植,人工周期和自然周期内膜准备方案并不影响妊娠结局。
Abstract
Objective To explore the impact of endometrial preparation protocols for single frozen-thawed euploid blastocyst transfer on pregnancy outcomes.Methods A total of 436 patients who underwent frozen-thawed transfer after preimplantation genetic screening (PGT-A) in the Reproductive Center of No. 924 Hospital of PLA from November 2015 to July 2019 were selected as the subjects. According to endometrial preparation methods, these patients were divided into two groups: the hormone replacement cycle group (HRT group) and the natural cycle group (NC group). The basic data and pregnancy outcomes were compared between the two groups.Results There was no significant difference in age, endometrial thickness or the distribution of PGT-A indications between the two groups (P>0.05). There was also no significant difference in the HCG positive rate, clinical pregnancy rate, abortion rate or live birth rate (P>0.05).Conclusions In the single frozen-thawed euploid blastocyst transfer cycle, pregnancy outcomes do not vary according to endometrial preparation protocols that should be selected flexibly according to the characteristics of menstruation and ovulation or according to the patient’s schedule.
关键词
胚胎植入前遗传学筛查 /
内膜准备 /
冻融胚胎移植
Key words
preimplantation genetic screening /
endometrial preparation /
frozen-thawed euploid blastocyst transfer
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参考文献
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基金
桂林市科学研究与技术开发计划项目(20170109-33);军队计划生育专项重点项目(17JS008)
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