衰弱与老年人认知功能障碍相关发病机制的研究进展

王影, 陈艺舟, 高明龙, 刘永哲

武警医学 ›› 2021, Vol. 32 ›› Issue (4) : 349-353.

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武警医学 ›› 2021, Vol. 32 ›› Issue (4) : 349-353.
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衰弱与老年人认知功能障碍相关发病机制的研究进展

  • 王影1, 陈艺舟1, 高明龙2 综述, 刘永哲3 审校
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衰弱 / 认知 / 作用机制

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王影, 陈艺舟, 高明龙, 刘永哲. 衰弱与老年人认知功能障碍相关发病机制的研究进展[J]. 武警医学. 2021, 32(4): 349-353
中图分类号: R459.9   

参考文献

[1] Canevelli M,Cesari M,van Kan G A, et al.Frailty and cognitive decline: how do they relate?[J].Curr Opin Clin Nutr Metab Care,2015,18(1): 43-50.
[2] Ma L, Zhang L, Sun F, et al. Cognitive function in prefrail and frail community-dwelling older adults in China[J]. BMC Geriatr, 2019, 19(1): 53.
[3] Yu R, Morley J E, Kwok T, et al. The effects of combinations of cognitive impairment and prefrailty on adverse outcomes from a prospective community-based cohort study of older chinese people[J]. Front Med, 2018, 5: 50.
[4] Feng L, Zin Nyunt M S, Gao Q,et al. Cognitive frailty and adverse health outcomes: findings from the singapore longitudinal ageing studies (SLAS)[J]. Am Med Dir Assoc, 2017, 18(3): 252-258.
[5] Chang C C, Hsu C Y, Huang P H, et al. Association between frailty and carotid intima media thickness and inflammatory marker in an elderly population[J]. Geriatr Gerontol Int, 2017, 17(10): 2449-2454.
[6] Walker K A, Walston J, Gottesman R F, et al. Midlife systemic inflammation is associated with frailty in later life: the aric study[J]. Gerontol A Biol Sci Med Sci, 2019, 74(3): 343-349.
[7] Mailliez A, Guilbaud A, Puisieux F, et al. Circulating biomarkers characterizing physical frailty: crp, hemoglobin, albumin, 25ohd and free testosterone as best biomarkers. results of a meta-analysis[J]. Exp Gerontol, 2020, 139: 111014.
[8] Lealdini V, Trufelli D C, da Silva F B, et al. Applicability of modified glasgo prognostic score in the assessment of elderly patients with cancer: a pilot study[J]. J Geriatr Oncol, 2015, 6(6): 479-483.
[9] Samson L D, Boots A M H, Verschuren W M M, et al. Frailty is associated with elevated crp trajectories and higher numbers of neutrophils and monocytes[J]. Exp Gerontol, 2019, 125: 110674.
[10] Ma L, Sha G, Zhang Y, et al. Elevated serum IL-6 and adiponectin levels are associated with frailty and physical function in chinese older adults[J]. Clin Interv Aging, 2018, 13: 2013-2020.
[11] Palmer J, Pandit V, Zeeshan M, et al. The acute inflammatory response after trauma is heightened by frailty: a prospective evaluation of inflammatory and endocrine system alterations in frailty[J]. Trauma Acute Care Surg, 2019, 7(1): 54-60.
[12] Nascimento C M C, Zazzetta M S, Gomes G A O, et al. Higher levels of tumor necrosis factor β are associated with frailty in socially vulnerable community-dwelling older adults[J]. BMC Geriatr, 2018, 18(1): 268.
[13] Bourdel-Marchasson I, Laksir H, Puget E, et al. Interpreting routine biochemistry in those aged over 65 years: a time for change[J]. Maturitas, 2010, 66(1): 39-45.
[14] Zheng F F, Xie W X. High-sensitivity c-reactive protein and cognitive decline: the english longitudinal study of ageing[J].Psychol Med, 2018, 48(8): 1381-1389.
[15] Ali N S, Hashem A H H, Hassan A M, et al. Serum interleukin-6 is related to lower cognitive functioning in elderly patients with major depression[J]. Aging Ment Health, 2018, 22(5): 655-661.
[16] Kim Y S, Lee K J, Kim H, et al. Serum tumour necrosis factor-α and interleukin-6 levels in Alzheimer’s disease and mild cognitive impairment[J]. Psychogeriatrics, 2017, 17(4): 224-230.
[17] Nevalainen T, Autio A, Kummola L, et al. CD27- Igd- bcell memory subset associates with inflammation and frailty in elderly individuals but only in males[J]. Immun Ageing, 2019, 16:19.
[18] Magalhães C A, Ferreira C N, Loures C M G, et al. Leptin, hscrp, tnf-α and il-6 levels from normal aging to dementia: relationship with cognitive and functional status[J]. Clin Neurosci, 2018, 56: 150-155.
[19] Karagüzel E Ö, Arslan F C, Uysal E K, et al. Blood levels of interleukin-1 beta, interleukin-6 and tumor necrosis factor-alpha and cognitive functions in patients with obsessive compulsive disorder[J]. Compr Psychiatry, 2019, 89: 61-66.
[20] Jiang J, Lv X, Liang B, et al. Circulating tnf-α levels increased and correlated negatively with Igf-I in postoperative cognitive dysfunction[J]. Neurol Sci, 2017, 38(8): 1391-1392.
[21] Peball M, Mahlknecht P, Werkmann M, et al. Prevalence and associated factors of sarcopenia and frailty in parkinson’s disease: a cross-sectional study[J]. Gerontology, 2019, 65(3): 216-228.
[22] Nishiguchi S, Yamada M, Fukutani N, et al. Differential association of frailty with cognitive decline and sarcopenia in community-dwelling older adults[J]. Am Med Dir Assoc, 2015, 16(2): 120-124.
[23] Delgado C, Doyle J W, Johansen K L, et al. Association of frailty with body composition among patients on hemodialysis[J]. Ren Nutr, 2015, 25(4): 397.
[24] Schaap L A, Pluijm S M, Deeg D J, et al. Health abc study. higher inflammatory marker levels in older persons: associations with 5 year change in muscle mass and muscle strength[J].J Gerontol A Biol Sci Med Sci, 2009, 64: 1183-1189.
[25] Nishiguchi S, Yamada M, Shirooka H, et al. Sarcopenia as a risk factor for cognitive deterioration in community-dwelling older adults: a 1-year prospective study[J]. J Am Med Direct Assoc, 2016, 17(4): 372, e5-8.
[26] Ogawa Y, Kaneko Y, Sato T, et al. Sarcopenia and muscle functionsat various stages of Alzheimer disease[J]. Front Neurol, 2018, 9:70.
[27] Cabett Cipolli G, Sanches Yassuda M, Aprahamian I, et al. Sarcopenia is associated with cognitive impairment in older adults: a systematic review and meta-analysis[J]. Nutr Health Aging, 2019, 23(6): 525-531.
[28] Koharak K,Okaday Y,Ochim M,et al.Muscle mass decline,arterial stiffness,white matter hyperintensity,and cognitive impairment: Japan shimanami health promoting pro-gram study[J]. Cachexia Sarcopenia Muscle,2017,8(4): 557-566.
[29] Beeri M S, Sonnen J.Brain bdnf expression as a biomarker for cognitive reserve agains Alzheimer disease progression[J]. Neurology, 2016, 86(8): 702-703.
[30] Deger S M, Hewlett J R, Gamboa J, et al. Insulin resistance is a significant determinant of sarcopenia in advanced kidney disease[J]. Physiol Endocrinol Metab, 2018, 315(6): E1108-E1120.
[31] Doi T, Shimada H, Makizako H, et al. Association of insulin-like growth factor-1 with mild cognitive impairment and slow gait speed[J]. Neurobiol Aging, 2015, 36: 942-947
[32] 陈 菲,李维辛. 肌少症与认知障碍相关性的研究进展[J]. 神经损伤与功能重建, 2020, 15(11): 641-644,651.
[33] Boulos C, Salameh P, Barberger-Gateau P, et al. Malnutrition and frailty in community dwelling older adults living in a rural setting[J]. Clin Nutr, 2016, 35: 138-143.
[34] Hong X, Yan J, Xu L, et al. Relationship between nutritional status and frailty in hospitalized older patients[J]. Clin Interv Aging, 2019, 14: 105-111.
[35] Verlaan S, Ligthart-Melis G C, Wijers S L J, et al. High prevalence of physical frailty among community-dwelling malnourished older adults-a systematic review and meta-analysis[J]. Am Med Dir Assoc, 2017, 18(5): 374-382.
[36] Wei K, Nyunt M S Z, Gao Q, et al. Frailty and malnutrition: related and distinct syndrome prevalence and association among community-dwelling older adults: singapore longitudinal ageing studies[J]. Am Med Dir Assoc, 2017, 18(12): 1019-1028.
[37] Cuesta-Triana F, Verdejo-Bravo C, Fernández-Pérez C, et al. Effect of milk and other dairy products on the risk of frailty, sarcopenia, and cognitive performance decline in the elderly: a systematic review[J]. Adv Nutr, 2019, 10(suppl 2): S105-S119.
[38] Ogaway Y,Kanekoy Y,Satoy T,et al.Sarcopenia and muscle functions at various stages of Alzheimer disease[J].Front Neurol,2018, 9: 710.
[39] Abdulan I M, Onofriescu M, Stefaniu R, et al. The predictive value of malnutrition for functional and cognitive status in elderly hemodialysis patients[J]. Int Urol Nephrol, 2019, 51(1): 155-162.
[40] Cheng D, Kong H, Pang W, et al. B Vitamin supplementation improves cognitive function in the middle aged and elderly with hyperhomocysteinemia[J]. Nutr Neurosci, 2016, 19(10): 461-466.
[41] Rietman M L, Spijkerman A M W, Wong A, et al. Antioxidants linked with physical, cognitive and psychological frailty: analysis of candidate biomarkers and markers derived from the mark-age study[J]. Mech Ageing Dev,2019,177: 135-143.
[42] Álvarez-Satta M, Berna-Erro A, Carrasco-Garcia E, et al. Relevance of oxidative stress and inflammation in frailty based on human studies and mouse models[J]. Aging (Albany NY), 2020, 12(10): 9982-9999.
[43] Soysal P, Isik A T, Carvalho A F, et al. Oxidative stress and frailty: a systematic review and synthesis of the best evidence[J]. Maturitas,2017,99: 66-72.
[44] 陆微微, 周 颖. 氧化应激在阻塞性睡眠呼吸暂停低通气综合征影响脑小血管病认知障碍中的作用[J]. 中华老年心脑血管病杂志, 2020, 22(12): 1247-1250.
[45] Nezevic D, Mizrahi R. Molecular imaging of neuroinflammation in Alzheimer’s disease and mild cognitive impairment[J]. Prog Neuro-Psychopharmacol Biol Psychiatry,2018, 80: 123-131.
[46] Liguori I, Russo G, Curcio F, et al. Oxidative stress, aging, and diseases[J]. Clin Interv Aging, 2018, 13: 757-772.
[47] 王 磊, 张 玲, 朱 梅,等. 血浆氧化应激标志物水平与慢性精神分裂症患者认知障碍的关系[J].中国医药科学, 2020, 10(13): 20-24.

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