目的 探讨老年高血压病患者血清末端脑钠肽前体(pro-brain natriuretic peptide,pro-BNP)、超敏C反应蛋白(high-sensitivity C-reactive protein,hs-CRP)与认知功能的相关性。方法 选取2019-01至2020-10就诊于武警陕西总队医院门诊及住院的高血压病患者178例。依据简易智力量表评分及蒙特利尔认知评分检测结果,分为无认知障碍组(117例)和认知障碍组(61例),比较两组患者血清pro-BNP及hs-CRP。结果 认知障碍组pro-BNP[(426.52±18.72)pg/ml]高于无认知障碍组[(120.36±15.61)pg/ml],差异有统计学意义(t=-115.965,P=0.000);认知障碍组hs-CRP[(3.91±0.46)ng/L]高于无认知障碍组[(3.27±0.52)ng/L],差异有统计学意义(t=-33.376,P=0.000)。结论 血清pro-BNP,hs-CRP与认知功能障碍的发生有密切的关系,提示在老年高血压病患者中,应重视监测pro-BNP及hs-CRP,对认知功能障碍的预防有重要的临床指导意义。
Abstract
Objective To investigate the correlations between levels of pro-natriuretic peptide precursor, hypersensitive C-reactive protein and cognition in elderly patients with hypertension. Methods A total of 178 patients with hypertension who were admitted to our hospital between January 2019 and October 2020 were included in this study. Serum levels of pro-BNP and hs-CRP were detected. The patients were divided into two groups: the cognitive impairment group (n=61) and non-cognitive impairment group (n=117) according to the MMSE score and Montreal Cognitive Assessment score. Results Serum levels of pro-BNP in the cognitive impairment group were significantly higher than those of the non-cognitive impairment group(426.52±18.72 pg/ml vs 120.36±15.61 pg/ml, P=0.000), so were the levels of hs-CRP in the cognitive impairment group(5.91±0.46 ng/L vs 3.27±0.52 ng/L,P=0.000). Conclusions Serum levels of pro-BNP and hs-CRP are closely related to the occurrence of cognitive dysfunction. It is suggested that these levels be monitored in the elderly patients with hypertension so as to prevent cognitive dysfunction.
关键词
高血压 /
脑钠肽前体 /
超敏C反应蛋白 /
认知功能
Key words
hypertension /
pro-brain natriuretic peptide /
high-sensitivity C-reactive protein /
cognitive function
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基金
武警陕西总队医院科研项目(YNKYLX-2019005)
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