目的 比较经胸超声心动图、经胸超声心动图联合右心声学造影、经食管超声心动图、经食管超声心动图联合右心声学造影四种检查方法对卵圆孔未闭(PFO)诊断的应用价值。方法 收集联勤保障部队第940医院2020-12至2021-11临床疑似PFO和经颅多普勒超声声学造影阳性患者87例为研究对象,所有患者同时行经胸超声心动图(TTE)、经胸超声心动图联合右心声学造影(c-TTE)、经食管超声心动图(TEE)和经食管超声心动图联合右心声学造影(c-TEE)检查,比较不同方法的PFO检出率,分析各自优缺点。结果 87例中,c-TEE检出PFO 71例(检出率81.61%),TEE检出PFO 56例(检出率64.37%),c-TTE检出PFO 47例(检出率54.02%),TTE检出PFO 23例(检出率为26.44%),四组之间差异有统计学意义(P<0.05)。c-TEE组阳性检出率高于c-TTE组(P<0.05),而c-TTE与TEE两组间阳性检出率差异无统计学意义(P=0.165)。Valsalva动作后,c-TEE组阳性检出率高于c-TTE组(P<0.05)。结论 四种方法比较,c-TEE、c-TTE、TEE对PFO阳性检出率均高于TTE,c-TEE检出的阳性患者最多。在Valsalva动作完成充分的情况下,c-TEE方法在显示PFO的结构形态、排查高危因素及RLS分级评定方面更具优势。
Abstract
Objective To compare the application value of TTE, C-TTE, TEE and C-TEE in the diagnosis of PFO. Methods Eighty-seven suspected patent foramen ovale and C-TCD positive patients in the 940th Hospital of Joint Logistics Support Force of PLA from December 2020 to November 2021 were collected as research objects. All patients underwent TTE, C-TTE, TEE and C-TEE tests. The detection rates of PFO of different methods were compared and their advantages and disadvantages were analyzed. Results Among 87 patients, 71 cases of PFO were detected by C-TEE method, and the detection rate was 81.61%. the data for TEE, C-TTE and TTE were respectively 56 cases(64.37%). 47 patients(54.02%) and 23 patients(26.44%), and the difference between the four groups was statistically significant (P<0.05). The positive rate of C-TEE group was higher than that of C-TTE group (P<0.05), but there was no significant difference between the positive rate of C-TTE and TEE (P=0.165). After VM, the positive rate of C-TEE group was higher than that of C-TTE group (P<0.05). Conclusions The positive rates of C-TEE, C-TTE and TEE for PFO are higher than those of TTE, and most PFO positive patients are detected by C-TEE. Under the condition that VM is fully completed, C-TEE method can provide more valuable information and advantages in displaying the structure and shape of PFO, screening high-risk factors and grading and even evaluating RLS.
关键词
c-TEE /
卵圆孔未闭 /
Valsalva动作 /
右向左分流
Key words
contrast transesophageal echocardiography /
patent foramen ovale /
valsalva maneuver /
right-to-left shunt /
positive detection rate
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参考文献
[1] Renard D,Ion I,Ricci J E,et al. Chronic small cortical cerebellar infarctions on MRI are associated with patent foramen ovale in young cryptogenic stroke[J].Cerebrovasc Dis, 2020, 49(1): 105-109.
[2] Friedrich S,Ng P Y,Platzbecker K,et al.Patent foramen ovale and long-term risk of ischemic stroke after surgery[J].Eur Heart J, 2019, 40(11):914-924.
[3] Le Moigne E,Timsit S,Ben Salem D,et al.Patent foramen ovale and ischemic stroke in patents with pulmonary embolism:a prospective cohort study[J].Ann Intern Med,2019,170(11):756-763.
[4] 冯 坤,邓 芸,王慧娟,等. 超声技术在卵圆孔未闭右向左分流检测中的应用进展[J]. 临床心血管病杂志,2019,35(7):590-594.
[5] Schneider B,Zienkiewicz T,Jansen V,et al.Diagnosis of patent foramen ovale by transesophageal echocardiography and correlation with autopsy findings[J]. Am J Cardiol,1996,77(14): 1202-1209.
[6] 王心宇,金 红,王 磊,等.右心声学造影在不明原因短暂性脑缺血发作中的应用[J].中国医学影像技术,2017,33(4):487-489.
[7] 李英华,笪应芬,朱 洋,等. 右心声学造影在隐源性卒中患者中的应用价值[J]. 影像研究与医学应用, 2021, 5(12):9-11.
[8] Zhao H,Yue Q,Wang T,et al.Sensitivity of contrast enhanced transthoracic echocardiography for the detection of residual shunts after percutaneous patent foramen ovale closure[J].Medicine(Baltimore),2019,98(4):e14276.
[9] Mahmoud A N,Elgendy I Y,Agarwal N,et al.Identification and quantification of patent foramen ovale mediated shunts:echocardiography and transcranial Doppler[J].Intrev Cardiol Clin,2017,6(4): 495-504.
[8] 冯 坤,邓 芸,王慧娟,等. 超声技术在卵圆孔未闭右向左分流检测中的应用进展[J]. 临床心血管病杂志,2019,35(7):590-594.
[9] Schneider B,Zienkiewicz T,Jansen V,et al.Diagnosis of patent foramen ovale by transesophageal echocardiography and correlation with autopsy findings[J]. Am J Cardiol,1996,77(14): 1202-1209.
[10] 杨 燕,梁春香,孙梦语,等. CTTE与TEE诊断成人单纯PFO的对比分析[J].中国超声医学杂志,2020, 36(9):814-817.
[11] 管 鑫,郑光美,胡 培,等. c-TEE 在诊断卵圆孔未闭中的应用价值[J].湖北医药学院学报,2021,40(1): 47-50.
[12] 郭 清.卵圆孔超声诊断的临床研究进展[J]. 微创医学,2018,13(6):769-771.
[13] 齐红艳,董菊芳,周 畅,等.经胸、经食管超声心动图及右心声学造影对卵圆孔未闭的诊断价值[J].巴楚医学,2021, 4(1):15-20.
[14] Marriott K,Manins V,Forshaw A,et al.Detection of right-to-left atrial communication using agitated saline contrast imaging: experience with 1162 patents and recommendations for echocardiography[J]. J Am Soc Echocardiogr,2013,26(1): 96-102.
[15] He J C,Zheng J Y,Li X,et al.Transthoracic contrast echocardiography using vitamin B6 and sodium bicarbonate as contrast agents for the diagnosis of patent foramen ovale[J].Int J Cardiovas Imag,2017,3(8):1125-1131.
[16] Osama I I S,Marcel L G,Folkert J M,et al.The use of contrast echocardiography for the detection of cardiac shunts[J]. Eur J Echocardiogr,2007,8(3): s2-12.
[17] Takaya Y,Watanabe N,Ikeda M,et al.Importance of abdominal compression Valsalva maneuver and microbubble grading in contrast transthoracic echocardiography for detecting patent foramen ovale[J]. J Am SocEchocardiogr,2020,33(2):201-206.
[18] Chen J,Chen L,Hu W,et al.A comparison of contrast transthoracic echocardiography and contrast transcranial Doppler in cryptogenic stroke patients with patent foramen ovale[J/OL].Brain Behav,2019,e01283.
[19] 庚靖淞,朱鲜阳,王琦光,等.经食管超声心动图联合右心声学造影在房间隔卵圆孔未闭中应用价值研究[J].临床军医杂志,2021, 49(5): 536-538.
[20] 段秉慧,黄 磊,尹玉良,等.经食管超声心动图联合右心声学造影诊断隐匿性脑卒中的应用[J].影响科学与光化学,2020,38(5): 855-861.
[21] 吕运梅,闫国珍,张黎琴,等.经胸右心声学造影联合经食管超声对不明原因脑卒中患者卵圆孔未闭的诊断价值[J].包头医学院学报,2021,37(4):10-13.