目的 探讨中国人群先天性白内障的危险因素,为降低先天性白内障的发生率提供依据。方法 检索CNKI、VIP、WanFang Data、Pubmed和Embase数据库,收集以上各数据库从建库至2021-11-30公开发表的有关先天性白内障危险因素的文献,运用RevMan5.4软件行 Meta分析。结果 本研究共纳入文献6篇,累计病例650例,对照1353例。Meta分析结果显示,中国人群先天性白内障的危险因素主要有:出生后给氧治疗(OR=5.50,95%CI:1.66～18.20)、家族遗传史(OR=6.97,95%CI:2.76～17.62)、孕期感染(OR=2.06,95%CI:1.38～3.06)、孕期营养状况不佳(OR=2.55,95%CI:1.17～5.56)、孕期服用药物(OR=4.49,95%CI:1.74～11.59)、患缺血缺氧性脑病(OR=6.42,95%CI:1.35～30.53)、早产(OR=2.14,95%CI:1.28～3.60)、低出生体重(OR=4.04,95%CI:2.11～7.75)、外周血血清补体C3水平下降(OR=1.04,95%CI:1.02～1.07)以及CRYAA和CRYAB基因单核苷酸多态性:CRYAArs7278468 GT+TT等位基因(OR=6.03,95%CI:1.27～28.53)、CRYABrs370803064 AA+GA等位基因(OR=5.81,95%CI:1.57～21.56)、CRYABrs387907338 TT+TC等位基因(OR=2.47,95%CI:1.34～4.58)、CRYAB基因TA单倍型(OR=1.80,95%CI:1.10～2.95)。结论 出生后给氧治疗、孕期感染、家族遗传史、孕期营养状况不佳、孕期服用药物、出生后诊断为缺血缺氧性脑病、早产、低出生体重、外周血血清补体C3水平下降、CRYAA和CRYAB基因单核苷酸多态性为先天性白内障发病的重要危险因素。
Abstract
Objective To explore the risk factors of congenital cataracts in Chinese population.Methods CNKI, VIP, WanFang Data, Pubmed and Embase databases were searched from inception to November 30th, 2021. Meta-analysis was conducted with RevMan5.4 software.Results Six articles were included, with a total of 650 cases and 1353 controls. The meta-analysis results showed that the risk factors for congenital cataract in the Chinese population were as follows, oxygen therapy after birth (OR=5.50, 95%CI: 1.66-18.20), family genetic history (OR=6.97, 95%CI: 2.76-17.62), infections during pregnancy (OR=2.06, 95%CI: 1.38-3.06), poor nutritional status during pregnancy (OR=2.55, 95%CI: 1.17-5.56), medications during pregnancy (OR=4.49, 95%CI: 1.74-11.59), suffering from ischemic hypoxic encephalopathy (OR=6.42, 95%CI: 1.35-30.53), premature delivery (OR=2.14, 95%CI: 1.28-3.60), low birth weight (OR=4.04, 95%CI: 2.11-7.75), peripheral blood serum complement C3 level decreased (OR=1.04, 95%CI: 1.02-1.07), CRYAA and CRYAB gene single nucleotide polymorphism: CRYAArs7278468 GT+TT allele (OR=6.03, 95%CI: 1.27-28.53), CRYABrs370803064 AA+GA allele (OR=5.81, 95%CI: 1.57-21.56), CRYABrs387907338 TT+TC allele (OR=2.47, 95%CI: 1.34-4.58), and CRYAB gene TA haplotype (OR=1.80, 95%CI: 1.10-2.95).Conclusions Congenital cataract is influenced by many factors, among which drug use during pregnancy, low birth weight, hypoxic ischemic encephalopathy and postnatal oxygen therapy are the most influential factors.
关键词
中国人 /
先天性白内障 /
发病 /
危险因素 /
Meta分析
Key words
Chinese /
congenital cataract /
incidence /
risk factors /
Meta-analysis
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基金
北航-首医大数据精准医疗高精尖创新中心同仁分中心开放基金项目(BHTR-KFJJ-202017)
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