目的 观察骶尾部藏毛窦切除术术后应用复方黄柏液的临床疗效。方法 回顾性分析2016-01至2021-06在武警安徽总队医院进行骶尾部藏毛窦治疗的38例武警战士的临床资料。根据术后是否采用复方黄柏液换药治疗分为观察组和对照组(外科常规治疗),每组19例。比较两组临床疗效、炎性指标、疼痛视觉模拟量表(VAS)、创面愈合时间等指标。结果 观察组患者创面愈合时间[(26.11±12.60)d]、住院时长[(22.68±16.32)d]明显短于对照组[(38.79±21.09)d、(34.32±24.50)d],观察组治疗后VAS评分[(1.11±0.80)分]低于对照组[(1.95±0.91)分],差异有统计学意义(P＜0.05)。观察组治疗总有效率高于对照组(94.74％ vs. 68.42％),差异有统计学意义(P=0.036)。随访3个月两组均无复发,6个月各有1例复发,在12个月对照组复发率高于观察组(10.53％ vs. 0),差异无统计学意义(P=0.146)。结论 完成藏毛窦切除手术后的患者,配合复方黄柏液换药治疗疗效显著,可以缓解官兵骶尾部活动疼痛,提高生活质量。
Abstract
Objective To examine the clinical efficacy of the use of compound Huangbai liquid after sacrococcygeal pilonidal sinus resection.Methods The clinical data of 38 officers and soldiers who were treated with sacrococcygeal pilonidal sinus in Anhui Provincial Corps Hospital from January 2016 to June 2021 were analyzed retrospectively. According to the use of compound Huangbai liquid after operation, the subjects were divided into observation group and control group(routine surgical care), with 19 cases in each group. Comparison was made between the different groups in clinical efficacy, the inflammatory index, the visual analogue scale, wound healing time and other indicators during the observation period in both groups.Results The wound healing time and hospital stay in the observation group [(26.11±12.60)and(22.68±16.32)d] were significantly shorter than those in the control group[(38.79±21.09)d and(34.32±24.50)d]. After treatment, the VAS score of the observation group [(1.11±0.80) points] was lower than that of the control group [(1.95±0.91) points], and the difference was statistically significant (P<0.05). The total effective rate of the observation group was higher than that of the control group (94.74％ vs. 68.42％), and the difference was statistically significant (P=0.036). There was no recurrence in the follow-up for 3 months, and 1 case recurred in the two groups at 6 months. The recurrence rate in the control group was higher than that in the observation group(10.53％ vs. 0)at 12 months, with no statistically significant difference(P=0.146).Conclusions Compound Huangbai liquid therapy is significantly effective, which can relieve the pain of sacral activity and improve the quality of the life of officers and soldiers.
关键词
武警官兵 /
藏毛窦 /
复方黄柏液 /
创面愈合 /
疗效
Key words
officers and soldiers of Chinese People's Armed Police Force /
pilonidal sinus disease /
compound huangbai liquid /
wound healing /
clinical effect
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参考文献
[1] Salih A M, Kakamad F H, Salih R Q, et al. Nonoperative management of pilonidal sinus disease: one more step toward the ideal management therapy-a randomized controlled trial [J]. Surgery, 2018, 164(1):66-70.
[2] Ates U, Ergun E, Gollu G, et al. Pilonidal sinus disease surgery in children: the first study to compare crystallized phenol application to primary excision and closure [J]. J Pediatr Surg, 2018, 53 (3):452-455.
[3] 娄宏达,张义君,刘燕青, 等. 藏毛窦的临床诊治进展研究[J]. 中国实用医药, 2020, 15 (9): 195-196.
[4] Iesalnieks I, Ommer A, Herold A, et al. German National Guideline on the management of pilonidal disease: update 2020 [J]. Langenbecks Arch Surg, 2021, 406 (8): 2569-2580.
[5] 杜 涛,张振宇,冷株赟, 等.美国结直肠外科医师协会2019版藏毛窦诊治临床实践指南[J].结直肠肛门外科,2019, 25(4): 363-374.
[6] Johnson E W. Visual analog scale (VAS) [J]. Am J Phys Med Rehabil, 2001, 80 (10):717.
[7] 徐旭英,杨博华,李友山, 等. 复方黄柏液涂剂治疗外伤感染的临床疗效研究[J]. 中国新药杂志, 2016, 25 (20):2349-2352.
[8] 国家中医药管理局.骶尾部囊肿窦的诊断依据、证候分类、疗效评定——中华人民共和国中医药行业标准《中医内科病证诊断疗效标准》(ZY/T001.1-94) [J]. 辽宁中医药大学学报, 2017, 19 (6):82.
[9] Grabowski J, Oyetunji T A, Goldin A B, et al. The management of pilonidal disease: a systematic review [J]. J Pediatr Surg, 2019, 54 (11):2210-2221.
[10] Gozukucuk A, Cakiroglu B, Yapici S, et al. Comparing crystallized phenol and surgical Excision treatments in pilonidal sinus disease [J]. J Coll Physicians Surg Pak, 2022, 32 (5):652-657.
[11] 汤灵娇,何 羽,姚齐贤. 复方黄柏液对肛周脓肿术后创面愈合的临床研究[J]. 中国临床药理学杂志, 2021, 37 (6): 668-670, 689.
[12] 李婉迪,栾 杰,穆大力. 手术治疗骶尾部藏毛疾病的现状与进展[J]. 中华整形外科杂志, 2020, 36 (9): 1062-1066.
[13] 宋丰安,向逸冰,胡高斌,等. 复方黄柏液涂剂超声引导下置管冲洗对内痈患者的临床疗效[J]. 中成药, 2022, 44 (3): 771-776.
[14] 孙绪丁,秦承雪. 复方黄柏液涂剂药理作用及其儿科的临床应用[J]. 世界最新医学信息文摘, 2019, 19 (2):31-33.
[15] 李嘉诚,吴 岚,蔡同凯,等. 黄柏化学成分及其药理作用研究进展[J]. 药学实践杂志, 2018, 36 (5): 389-391, 398.
[16] 丁晓彦, 林志军,王 岱. 金银花-连翘药对的成分和药理作用研究进展[J]. 山东科学, 2019, 32 (3): 36-41.
[17] Lorant T, Ribbe I, Mahteme H, et al. Sinus excision and primary closure versus laying open in pilonidal disease: a prospective randomized trial [J]. Dis Colon Rectum, 2011, 54 (3): 300-305.
[18] Norooznezhad A H. Decreased pain in patients undergoing pilonidal sinus surgery treated with platelet-rich plasma therapy: the role of angiogenesis [J]. Adv Skin Wound Care, 2020, 33 (1): 8.
基金
武警部队学科拔尖人才基金(〔2020〕901号);安徽省自然科学基金项目(1908085MH261)
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