目的 探讨肿瘤标志物甲胎蛋白(Alpha fetoprotein,AFP)、癌胚抗原(Carcinoembryonic antigen,CEA)、铁蛋白(Serum ferritin,SF)及β2-微球蛋白(β2-microglobulin,β2-MG)检测对于冠心病和高血压病患者诊治及预后判断的价值。方法 选择2017-02至2019-03就诊的部队官兵中冠心病患者40例(冠心病组)、高血压患者40例(高血压组)、冠心病合并高血压患者40例(冠心病合并高血压组)为研究对象,另选择同期在我院接受健康体检的健康官兵40例为对照组。采集4组受检者空腹静脉血,检测并对比各组间血清AFP、CEA、SF及β2-MG水平差异,记录冠心病组、高血压组和冠心病合并高血压组血清SF、β2-MG阳性检出率。结果 高血压组、冠心病组、冠心病合并高血压组AFP、CEA水平与对照组相比,差异无统计学意义;高血压组中β2-MG为(3.60±1.83)ng/mL、SF为(202.96±99.06)ng/ml,冠心病组中β2-MG为(3.41±1.31)ng/ml、SF为(200.84±103.29)ng/ml,冠心病合并高血压组中β2-MG为(3.63±1.82)ng/ml、SF为(207.43±104.89)ng/ml,对照组中β2-MG为(2.16±0.51)ng/ml、SF为(114.66±74.31)ng/ml,差异有统计学意义(P＜0.05);高血压、冠心病、冠心病合并高血压三组患者的血清β2-MG、SF检测数值、阳性检出率比较,差异无统计学意义。结论 β2-MG和SF参与了冠心病合并高血压、高血压、冠心病的病理生理过程,可将β2-MG和SF作为临床诊治及判断预后及疗效的参考指标。
Abstract
Objective To investigate the changes and clinical significance of serum levels of alpha fetoprotein (AFP), carcinoembryonic antigen (CEA), serum ferritin (SF) and β2-microglobulin (β2-MG) in patients with coronary heart disease (CHD) and hypertension.Methods From among the military outpatients who had visited Beijing Municipal Corps Hospital of Chinese People’s Armed Police Force between February 2017 and March 2019, 40 CHD patients (CHD group), 40 with hypertension (HTN group), and 40 with both CHD and hypertension (CHD and HTN group) were selected as the subjects, while another 40 healthy people served as the control group. The fasting venous blood of the four groups was tested. The levels of serum AFP, CEA, SF and β2-MG in the four groups were detected and compared. The positive detection rates of serum SF and β2-MG in the CHD group, HTN group and CHD and HTN group were recorded.Results There was no statistically significant difference in levels of AFP or CEA between the three groups and the control group (P>0.05). However, there was statistically significant difference in levels of β2-MG and SF between the HTN group [(3.60±1.83)ng/mL, (202.96±99.06)ng/mL], CHD group [(3.41±1.31)ng/mL, (200.84±103.29)ng/mL], CHD and HTN group [(3.63±1.82)ng/mL, (207.43±104.89)ng/mL]and the control group [(2.16±0.51)ng/mL, (114.66±74.31)ng/mL] (P<0.05). There was no statistically significant difference in the positive detection rate of serum β2-MG or SF between the HTN group, CHD group and CHD and HTN group(P>0.05).Conclusions The levels of CEA and AFP remain unchanged in patients with HTN, CHD and CHD and HTN. β2-MG and SF participate in the physiological and pathological processes of HTN, CHD and CHD and HTN so that β2-MG and SF can be used as indexes for clinical diagnosis of prognosis and efficacy.
关键词
甲胎蛋白 /
癌胚抗原 /
铁蛋白 /
β2-微球蛋白 /
冠心病 /
高血压
Key words
alpha fetoprotein /
carcinoembryonic antigen /
serum ferritin /
β2-microglobulin /
coronary heart disease /
hypertension
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参考文献
[1] 熊宇麒,李学军.心血管疾病与恶性肿瘤的共同危险因素及药物的影响[J].药学学报,2020,55(1):1-7.
[2] Meijers WC,de Boer RA. Common risk factors for heart failure and cancer [J]. Cardiovasc Res,2019, 115: 844-853.
[3] Li KHC,Gong M,Li G, et al. Cancer antigen.125 and outcomes in acute heart failure: a systematic review and meta-analysis[J].Heart Asia,2018,10:11-44.
[4] 中国高血压防治指南修订委员会.中国高血压防治指南2010[J].中国高血压杂志,2011,19(8):701.
[5] 中华医学会心血管病学分会,中华心血管病杂志编辑委员会.冠心病诊断和治疗指南(2007版)[J].中华心血管病杂志,2007,35(3):195-206.
[6] 庞敏红,卢志红.多项瘤标记物联合检测对原发性肝癌诊断的价值[J].海南医学院学报,2015,21(11):1581-1583.
[7] 刘存芬.尿转铁蛋白和血清β2-微球蛋白联合检测对高血压肾病的诊断意义[J].检验医学与临床,2014,11(18):2600-2601.
[8] Ruanphoo P,Phupong V.Evaluation of the performance of the insulin-like growth factor-binding protein-1/alpha-fetoprotein test in diagnosing ruptured fetal membranes in pregnant women[J].J Perinatol,2015,35(8):558-560.
[9] 李 争,李 强,肖 强.甲胎蛋白、癌胚抗原和糖链抗原19-9联合检测诊断消化系统恶性肿瘤的价值分析[J].癌症进展,2017,17(4):432-434.
[10] 鹿存芝,李向阳.甲胎蛋白联合CA199、AFU及CEA在原发性肝癌中的诊断价值[J].检验医学与临床,2017,14(10):1412-1414.
[11] 王 琼,喻 勇,曾 智,等.乙肝患者癌胚抗原、甲胎蛋白水平与生化应答间的相关性[J].湖南师范大学学报(医学版),2016,13(6):8-10.
[12] 吴晓颖,俞 晴,陶 怡.铁蛋白对多发性骨髓瘤诊断中的临床意义[J].武警医学,2018,12(29):1144-1147.
[13] Skandalis K,Vlachos C,Pliakou X,et al.Higher Serum Ferritin Levels Correlate with an Increased Risk of Cutaneous Morbidity in Adult Patients with β-Thalassemia: A Single-Center Retrospective Study[J].Acta Haematol,2016,135(2):124-130.
[14] 刘丽娟.感染性疾病患者血清铁蛋白、β2微球蛋白的表达及临床意义[J].中国医药导报,2014,11(8):38-40.
[15] Huang T,Li K,Asimi S,et al.Effect of vitamin B-12 and n-3 polyunsaturated fatty acids on plasma homocysteine, ferritin, C-reaction protein, and other cardiovascular risk factors: a randomized controlled trial[J].Asia Pac J Clin Nutr,2015,24(3):403-411.
[16] 卢 文,刘淑华,李 婷,等.老年高血压患者胱抑素C和视黄醇结合蛋白及β2微球蛋白的表达和作用[J].中华老年医学杂志,2015,34(5):487-490.
[17] 任可可,宿克昌.血清胱抑素C及β2微球蛋白检测与冠心病的相关性研究[J].中西医结合心脑血管病杂志,2014,12(5):554-555.
[18] 马 军,蒋金法.高血压合并冠心病患者血、尿β2微球蛋白测定的临床意义[J].同济大学学报,2009,30(6):50-52.
[19] 李 烨,胡世莲,袁庆婷,等.老年慢性病患者铁代谢异常与慢性病的相关性[J].中国临床保健杂志,2019,22(4):459-463.
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