目的 探讨血清降钙素原(procalcitonin, PCT)、血清超敏C反应蛋白(high-sensitivityc-reactiveprotein, hs-CRP)、外周血白细胞(white blood cells, WBC)、白细胞介素-6(interleukin- 6,IL-6)、血红蛋白(hemoglobin,Hb)在儿童细菌感染性肺炎的水平变化及与病情严重程度的相关性。方法 选取2019-03至2021-03武警江西总队医院收治的98例细菌感染性肺炎患儿为试验组,选取同期健康体检儿童98例作为对照组。根据临床肺部感染评分评估病情,将试验组划分为重症组和轻症组,采集全部受试者血清,利用统计学软件分析各组间血清PCT、hs-CRP、WBC、IL-6、Hb与病情严重程度的相关性,对连续变量进行Logistic回归分析。结果 试验组PCT、hs-CRP、WBC、IL-6均高于对照组,对照组PCT(μg/ml)表达(0.27±0.12)＜轻症组(1.98±0.43)＜重症组(2.04±0.45);对照组hs-CRP(mg/L)表达(5.64±2.37)＜轻症组(21.27±9.13)＜重症组(26.84±9.32);对照组WBC(×10⁹/L)表达(10.46±2.95)＜轻症组(23.05±3.79)＜重症组(26.27±5.21);对照组IL-6(pg/L)表达(10.23±2.46)＜轻症组(62.45±9.43)＜重症组(96.43±12.03);重症组Hb(g/L)表达(123.43±14.85)＜轻症组(126.58±16.53)＜对照组(135.24±14.74),差异均有统计学意义(P＜0.05)。PCT、hs-CRP、WBC、IL-6与患儿患病的严重程度呈正相关的r值分别为0.085、0.910、0.941、0.957、-0.738。经Logistic回归模型分析,PCT、hs-CRP、WBC、IL-6、Hb是影响细菌感染性肺炎患儿病情进展的独立危险因素。结论 血清PCT、hs-CRP、WBC、IL-6、Hb与细菌感染性肺炎患儿的病情严重情况具有相关性,联合检测可为判断患儿早期细菌感染性肺炎提供依据。

Objective To investigate the correlation between serum procalcitonin ( PCT), serum high-sensitivity-reactive protein(hs-CRP), white blood cells(WBC), interleukin-6 (IL-6), hemoglobin (Hb) level changes and the severity of bacterial infectious pneumonia in children.Methods Ninety-eight children with bacterial infectious pneumonia admitted to our hospital from March 2019 to March 2021 were selected as the study subjects, and another 98 children with health examination during the same period were selected as the control group. Continuous variables were evaluated according to the clinical lung infection scores and divided into severe and mild groups, and the association between serum PCT, hs-CRP, WBC, IL-6, and Hb and disease severity was analyzed using statistical software. Serum from all subjects was collected for analysis, and the data showed that the levels of PCT, hs-CRP, WBC and IL-6 in the study group compared with the control group.Results The expression of PCT(μg/ml) in the control group (0.27±0.12) <mild group (1.98±0.43) <severe group (2.04±0.45); the hs-CRP (mg/L) expression in the control group (5.64±2.37) <mild group (21.27±9.13) <severe group (26.84±9.32); the expression of WBC (×10⁹/L) in the control group (10.46±2.95) <mild group (23.05±3.79) <severe group (26.27±5.21); the expression of IL-6(pg/L) in the control group (10.23±2.46) <mild group (62.45±9.43) <severe group (96.43±12.03); the expression of Hb(g/L) in the severe group (123.43±14.85) <mild group (126.58±16.53) <control group (135.24±14.74).The difference was statistically significant (P＜0.05).Moreover, with a positive correlation with the severity of the disease, the r-values of PCT, hs-CRP, WBC, IL-6, and Hb were 0.085,0.910,0.941,0.957, and -0.738, respectively. According to the Logistic regression model analysis, PCT, hs-CRP, WBC, IL-6, and Hb were the independent risk factors affecting the disease progression of children with bacterial infectious pneumonia (P<0.05).Conclusions Serum PCT, hs-CRP, WBC, IL-6 and Hb are related with the serious condition of children with bacterial infectious pneumonia, which can provide diagnostic basis for combined diagnostic indicators for early bacterial infectious pneumonia in children.