抗真菌性外耳道炎药物载体应用于真菌性外耳道炎的临床效果

张旭东, 李楠, 刘清源, 王倩, 郇颖静, 张莉

武警医学 ›› 2022, Vol. 33 ›› Issue (6) : 461-463.

PDF(950 KB)
PDF(950 KB)
武警医学 ›› 2022, Vol. 33 ›› Issue (6) : 461-463.
论著

抗真菌性外耳道炎药物载体应用于真菌性外耳道炎的临床效果

  • 张旭东1, 李楠1, 刘清源2, 王倩1, 郇颖静1, 张莉1
作者信息 +

Clinical effect of antifungal drugs supporter on fungal otitis externa

  • ZHANG Xudong1, LI Nan1, LIU Qingyuan2, WANG Qan1, HUAN Yingjing1, ZHANG Li1
Author information +
文章历史 +

摘要

目的 观察抗真菌性外耳道炎药物载体应用于武警官兵真菌性外耳道炎的临床效果。方法 选取武警河南总队医院 2017-01至2020-12就诊的武警官兵真菌性外耳道炎患者 85 例(109耳),随机分为载体组和对照组。两组患者均首先清洁病变区域,并给予病变区域抗真菌软膏涂抹,完成治疗后,载体组置入抗真菌外耳道炎药物载体,对照组患者自行涂抹抗真菌软膏,每日 1或2 次。2周后复诊,比较两组疗效;比较两组6个月后复发率。结果 对照组治疗总有效率为 55.81%(24/43),明显低于载体组的 95.23%(40/42),差异有统计学意义(P<0.05)。载体组复发率 2.50%(1/40),对照组复发率 29.17%(7/24), 对照组复发率明显高于载体组,差异有统计学意义(P<0.05)。结论 抗真菌性外耳道炎药物载体应用于武警官兵真菌性外耳道炎,可以提高疗效,值得临床推广应用。

Abstract

Objective To observe the clinical effect of antifungal drugs supporter on fungal otitis externa.Methods Eighty-five patients with fungal otitis externa who were admitted to the hospital from January 2017 to December 2020 were randomly divided into two groups (treatment group and control group). The control group were applied with antifungal ointment by the patients themselves, while the treatment group were treated with antifungal drugs supporter. The curative effect was compared 2 weeks later and the recurrence rate was surveyed 6 months later.Results The total effective rates in the treatment group were significantly higher than those in the control group (95.23% vs. 55.81%), and there was significant difference (P<0.05). The recurrence rate in the treatment group were lower than that in the control group (2.50% vs. 29.17%), and there was also significant difference (P<0.05).Conclusions The clinical effect of antifungal drugs supporter which is clear in the treatment of fungal otitis externa is worthy of clinical application.

关键词

真菌性外耳道炎 / 抗真菌药物载体 / 复发

Key words

fungal otitis externa / antifungal drugs supporter / recurrence

引用本文

导出引用
张旭东, 李楠, 刘清源, 王倩, 郇颖静, 张莉. 抗真菌性外耳道炎药物载体应用于真菌性外耳道炎的临床效果[J]. 武警医学. 2022, 33(6): 461-463
ZHANG Xudong, LI Nan, LIU Qingyuan, WANG Qan, HUAN Yingjing, ZHANG Li. Clinical effect of antifungal drugs supporter on fungal otitis externa[J]. Medical Journal of the Chinese People Armed Police Forces. 2022, 33(6): 461-463
中图分类号: R443.6   

参考文献

[1] 张思思, 林川耀, 陆 玲. 耳内镜下不同给药频率曲安奈德益康唑乳膏治疗真菌性外耳道炎的疗效观察[J].中国中西医结合耳鼻咽喉科杂志, 2018, 26(4):253-256.
[2] 孔维佳, 周 梁. 耳鼻咽喉头颈外科学[M]. 3 版.北京:人民卫生出版社, 2015:116-117.
[3] 廖万青, 陈 敏, 方文捷.医学真菌研究的前沿及热点[J].新发传染病电子杂志,2018, 3(3):129-133.
[4] Fisher M,Dietz A,Acute external otitis and its differential diagnosis[J].Laryngorhinootogie, 2015,94(2):113-125.
[5] 赵龙珠,肖晶晶,杨立强, 等. 醋酸曲安奈德益康唑乳膏治疗外耳道炎性反应的疗效[J].武警医学, 2020,31(9):786-788.
[6] 赵 鹏. 5%碳酸氢钠耳浴联合制霉菌素粉治疗真菌性外耳道炎的疗效观察[J].现代药物与临床, 2019,34(5): 1446-1448.
[7] Agarwal P,Devi L S. Otomycosis in arural community attending a tertiary care hospital: assessment of risk factors and identification of fungal and bacterial agents[J].J Clin Diagn Res, 2017, 11(6): DC14-DC18.
[8] Pal’chun V T,Gurov A V,Yushkina M A.Symptomatic approach to diagnosis and treatment of inflanlmatol diseases of the outer ear[J].Vestn Otorinolaringol,2019,84(3):46-50.
[9] 姜泗长,顾 瑞,王正敏.耳鼻咽喉科全书[M].2版.上海:上海科学技术出版社, 2002:612.
[10] Stevens S M, Lambert P R, Baker A B, et al. Malignant otitis externa: a novel stratification protocal for predicting treatment outcomes[J].Otol Neurotol,2015, 36(9): 1492-1498.
[11] 李永奇,何理风. 耳内镜下抗真菌药局部注入治疗真菌性外耳道炎[J].中国临床研究, 2020, 33(1): 88-91.
[12] EL-Konmy M H M,Saleh N A,Saleh M A. Autologous platelet-rich plasma and triamconolone acetonide intralesional injection in the treatment of oral erosions of pemphigus vulgaris:a pilot study[J].Arch Dermatol Res,2018,310(1):375-381.
[13] Vennewwald I,Klemn E. Otomycosis:diagnosis and treatment[J].Clin Dermatol,2010,28(2):202-211.
[14] 陈凤明, 肖小玲, 曾国强, 等.微信式延续护理对真菌性外耳道炎患者心理及治疗效果的影响[J].广州医药, 2020,51(4):100-103.

PDF(950 KB)

Accesses

Citation

Detail

段落导航
相关文章

/