目的 探讨密闭驻训环境下新兵应激反应变化及其对认知功能的影响。方法 以某部首次遂行密闭驻训任务的新兵(新训后新兵)97人为研究组,均为男性,以同期驻训老兵(兵龄＞2年,密闭驻训≥2次)46人为对照组,均为男性。以驻训前1周+驻训期为观察期,采用酶联免疫吸附法(ELISA)连续监测入组对象的唾液皮质醇(salivary cortisol, SC)浓度;以驻训第2周为观察断面,采用北京版蒙特利尔认知评估量表(Montreal cognitive assessment-Beijing,MoCA-BJ)测评其认知功能。比较两组的SC浓度和MoCA-BJ评分,并分别对研究组和对照组进行SC浓度与MoCA-BJ评分的相关性分析。结果 研究组纳入92人,对照组纳入43人。(1)研究组SC升高较对照组出现早,峰值高,持续时间长,驻训前3周SC浓度均显著高于对照组同期水平(P＜0.01);(2)研究组驻训第2周MoCA-BJ评分总分(22.87±1.65)低于对照组(27.32±1.53),差异有统计学意义(t=13.72,P＜0.01);(3)研究组SC浓度与MoCA-BJ评分显著负相关(rs=-0.426,95% CI:-0.511～-0.331,P＜0.01),而对照组SC浓度与MoCA-BJ评分无相关性(rs=0.236,P＞0.05)。结论 新兵密闭驻训期间应激反应较老兵强烈,应加强对认知功能损伤的防治。
Abstract
Objective To explore changes of stress of new recruits trained in closed environment, and the influence of stress on cognitive function.Methods Ninety-seven male new recruits of a certain army were chosen as the study group who had finished the routine training for new recruits and were taking the mission of training in closed environment for the first time. Forty-six male veterans trained in closed environment at the same time served as the control group who had been in army service for more than two years and had trained in closed environment for no less than twice. With the week before training and the training period as the observational period, ELISA was employed to monitor salivary cortisol(SC) concentrations of subjects successively. With the second week of training as the observational section, MoCA-BJ was employed to assess their cognitive function. The SC concentrations and MoCA-BJ scores were compared between the two groups, and the relevance of SC concentrations to MoCA-BJ scores was analyzed respectively.Results Ninety-two men were admitted to the study group, and 43 men were admitted to the control one. Compared with the control group, SC of the study group increased earlier, peaked higher, lasted longer, and its SC concentrations of the first three weeks after the training were higher than those in the control group significantly (P＜0.01). In the second week, the total MoCA-BJ score in each group of the study group (22.87±1.65) was lower than that of the control one (27.32±1.53), and the difference was statistically significant (t=13.72,P＜0.01). SC concentrations of the study group were correlated negatively with MoCA-BJ scores statistically(rs=-0.426,95% CI:-0.511--0.331,P＜0.01),while SC concentrations of the control group were uncorrelated with MoCA-BJ scores(rs=0.236,P＞0.05).Conclusion During training in closed environment, the new recruits show stronger stress than the veterans so the prevention and treatment ofcognitive function should be paid more attention.
关键词
军事医学 /
密闭环境 /
环境暴露 /
应激 /
认知功能
Key words
military medicine /
closed environment /
environmental exposure /
stress /
cognitive function
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基金
全军十二五重点课题(D101100050010042)
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