[1] 王 健,刘 辉,李 成,等.低海拔地区官兵进驻高原后血液指标的变化[J].武警医学,2020,31(9):762-764. [2] Li Z B, Chen H Y, Li J Y, et al. Clinical, laboratory and imaging features of high altitude pulmonary edema in Tibetan Plateau[J]. Chin Med Sci J, 2018, 33(3):160-173. [3] Swenson E R. Early hours in the development of high-altitude pulmonary edema: time course and mechanisms[J]. J Appl Physiol (1985), 2020, 128(6):1539-1546. [4] 刘小云,孙 莉,胡小兵.部队进驻高原急性高原病预防策略分析[J].武警医学,2021,32(11):995-998. [5] Luks A M, Auerbach P S, Freer L, et al. Wilderness medical society clinical practice guidelines for the prevention and treatment of acute altitude illness: 2019 update [J]. Wilderness Environ Med, 2019, 30(4S):S3-S18. [6] Zhang X, Xie L, Long J, et al. Salidroside: A review of its recent advances in synthetic pathways and pharmacological properties[J]. Chem Biol Interact, 2021, 339:109268. [7] Wang N, Song J, Zhou G, et al. Mechanism of salidroside relieving the acute hypoxia-induced myocardial injury through the PI3K/Akt pathway[J]. Saudi J Biol Sci, 2020, 27(6):1533-1537. [8] Nan X, Su S, Ma K, et al. Bioactive fraction of rhodiola algida against chronic hypoxia-induced pulmonary arterial hypertension and its anti-proliferation mechanism in rats[J]. J Ethnopharmacol, 2018, 216:175-183. [9] Li Y, Zhang Y, Zhang Y. Research advances in pathogenesis and prophylactic measures of acute high altitude illness[J]. Respir Med, 2018, 145:145-152. [10] Young J M, Williams D R, Thompson A. Thin air, thick vessels: historical and current perspectives on hypoxic pulmonary hypertension[J]. Front Med (Lausanne), 2019, 6:93. [11] Smadja D M, Mauge L, Sanchez O, et al. Distinct patterns of circulating endothelial cells in pulmonary hypertension[J]. Eur Respir J, 2010, 36(6):1284-1293. [12] Wang T, Hou J, Xiao W, et al. Chinese medicinal plants for the potential management of high-altitude pulmonary oedema and pulmonary hypertension[J]. Pharm Biol, 2020, 58(1):815-827. [13] Chang P K, Yen I C, Tsai W C, et al. Protective effects of rhodiola crenulata extract on hypoxia-induced endothelial damage via regulation of AMPK and ERK pathways[J]. Int J Mol Sci, 2018, 19(8):1435-1442. [14] Soree P, Gupta R K, Singh K, et al. Raised HIF1α during normoxia in high altitude pulmonary edema susceptible non-mountaineers[J]. Sci Rep, 2016, 6: 26468. [15] 卜 婧,张永亮,李灵芝,等.侧链失碳红景天苷类似物N04对缺氧EA.hy926内皮细胞缺氧诱导因子及其相关因子的影响[J].医学研究生学报, 2017, 30(8):798-803. [16] Gui D, Cui Z, Zhang L, et al. Salidroside attenuates hypoxia-induced pulmonary arterial smooth muscle cell proliferation and apoptosis resistance by upregulating autophagy through the AMPK-mTOR-ULK1 pathway[J]. BMC Pulm Med, 2017, 17(1):191. [17] 毛稼琦,刘川川,张雨薇,等.红景天苷对低氧诱导的大鼠肺动脉平滑肌细胞表型转化的影响[J].中国中药杂志,2022,47(4):1024-1030. [18] Huang X, Zou L, Yu X, et al. Salidroside attenuates chronic hypoxia-induced pulmonary hypertension via adenosine A2a receptor related mitochondria-dependent apoptosis pathway[J]. J Mol Cell Cardiol, 2015,82:153-166. [19] 李风峰,康金旺,吕建东,等.红景天苷对低氧性肺动脉高压大鼠肺组织炎性因子表达的影响[J].中国临床药理学杂志, 2019, 35(10):996-999. [20] Sharma K R, Mishra R, Gautam J, et al. Patchy vasoconstriction versus inflammation: a debate in the pathogenesis of high altitude pulmonary edema [J]. Cureus, 2020, 12(9):e10371. [21] Gojkovic M, Darmasaputra G S, Velişa P, et al. Deregulated hypoxic response in myeloid cells: A model for high-altitude pulmonary oedema (HAPE)[J]. Acta Physiol (Oxf), 2020, 229(2): e13461. [22] 关 爽.红景天苷的抗炎作用及其对炎症信号转导通路的调控[D].长春:吉林大学,2011. [23] Gambhir S, Vyas D, Hollis M, et al. Nuclear factor kappa B role in inflammation associated gastrointestinal malignancies [J]. World J Gastroenterol, 2015, 21(11):3174-3183. [24] You L, Zhang D, Geng H, et al. Salidroside protects endothelial cells against LPS-induced inflammatory injury by inhibiting NLRP3 and enhancing autophagy[J]. BMC Complement Med Ther, 2021, 21(1):146. [25] Hu R, Wang M Q, Ni S H, et al. Salidroside ameliorates endothelial inflammation and oxidative stress by regulating the AMPK/NF-κB/NLRP3 signaling pathway in AGEs-induced HUVECs[J]. Eur J Pharmacol, 2020, 867:172797. [26] Cai W, Liu Z, Li G, et al. The effects of a graded increase in chronic hypoxia exposure duration on healthy rats at high-altitude [J]. Int J Clin Exp Pathol, 2019, 12(6):1975-1991. [27] Cai W, Liu S, Liu Z, et al. Downregulation of lung miR-203a-3p expression by high-altitude hypoxia enhances VEGF/Notch signaling[J]. Aging (Albany NY), 2020, 12(5): 4247-4267. [28] Lee S Y, Li M H, Shi L S, et al. Rhodiola crenulata extract alleviates hypoxic pulmonary edema in rats [J]. Evid Based Complement Alternat Med, 2013, 2013:718739. [29] 张兴凯,沙马阿直,冯 菁,等.红景天苷抑制低氧诱导的血管渗出[J]. 西北国防医学杂志, 2016, 37(9): 605-607. [30] Magnani N D, Dada L A, Queisser M A, et al. HIF and HOIL-1L-mediated PKCζ degradation stabilizes plasma membrane Na, K-ATPase to protect against hypoxia-induced lung injury[J]. Proc Natl Acad Sci U S A, 2017, 114(47):E10178-E10186. [31] 谭春燕.红景天苷抗高原缺氧作用研究[D]. 拉萨:西藏大学, 2015. [32] Zhu Z, Li J, Zhang X. Salidroside protects against ox-LDL-induced endothelial injury by enhancing autophagy mediated by SIRT1-FoxO1 pathway [J]. BMC Complement Altern Med, 2019, 19(1):111. [33] 肖 梨,佟晓永.肺动脉高压形成中的血管重构分子生物学机制研究进展[J].浙江大学学报(医学版),2019,48(1):102-110. [34] 张艳梅,金 强.红景天苷对野百合碱诱导大鼠肺动脉高压及肺血管重塑影响[J].临床军医杂志, 2016, 44(7): 712-715.