目的 分析益生菌联合含呋喃唑酮四联疗法根除幽门螺杆菌(Helicobacter pylori,Hp)的疗效。方法 选取2022-03至2022-10两批次驻吉林某部入伍新兵共计Hp阳性感染者403例,按随机数字表法分为对照组(201例)及观察组(202例)。对照组治疗药物:雷贝拉唑肠溶胶囊,20 mg/次,2次/d,早晚饭前服用;阿莫西林1000 mg/次,2次/d,早晚饭后服用;呋喃唑酮 0.1 g/次,2次/d,早晚饭后服用;胶体果胶铋胶囊200 mg/次,2次/d,早晚饭前服用,疗程14 d。观察组在上述四联药物基础上加用益生菌(双歧杆菌四联活菌片),3片/次,3次/d。停药4周后复查13C呼气试验,评估Hp根除率,同时对治疗中出现的不良反应进行监测汇总。结果 按ITT分析对照组根除率为88.06%,观察组为87.13%,两组差异无统计学意义(χ2=0.080,P=0.777)。按PP分析两组根除率,对照组为88.06%,观察组为87.56%,差异无统计学意义(χ2=0.023,P=0.879)。两组不良反应发生率对照组为14.52%,观察组为8.91%,差异有统计学意义(χ2=4.000,P=0.045)。结论 益生菌联合呋喃唑酮四联疗法能降低不良反应发生率,但对根除率无明显提升。
Abstract
Objective To analyze the effect of probiotics combined with furazolidone quadruple therapy on eradication of Helicobacter pylori (Hp). Methods A total of 403 Hp-positive new recruits were selected from two batches from March to October 2022 and were divided into control group and observation group using a random number table. The control group received rabeprazole enteric-coated capsules at a dose of 20 mg, twice daily before breakfast and dinner, amoxicillin at a dose of 1000 mg, twice daily after breakfast and dinner, furazolidone at a dose of 0.1 g, twice daily after breakfast and dinner, and colloidal bismuth pectin capsules at a dose of 200 mg, twice daily before breakfast and dinner. The treatment duration was 14 days. The observation group received the same quadruple therapy plus probiotics (bifidobacterium quadruple active tablets) at a dose of 3 tablets, three times daily. After a 4-week drug withdrawal, the 13C breath test was conducted to evaluate the Hp eradication rate. Adverse reactions during treatment were monitored and summarized for statistical analysis. Results The Hp eradication rate in the control group was 88.06% (ITT analysis) and 87.13% (ITT analysis) in the observation group, with no statistically significant difference between the two groups (χ2=0.080,P=0.777). The PP analysis showed eradication rates of 88.06% in the control group and 87.56% in the observation group, with no statistically significant difference (χ2=0.023,P=0.879). The incidence of adverse reactions was 15.4% in the control group and 8.9% in the observation group, with a significant difference in the occurrence of adverse reactions (χ2=4.000,P=0.045). Conclusions Probiotics combined with furazolidone quadruple therapy can reduce the incidence of adverse reactions, but do not significantly improve the eradication rate.
关键词
幽门螺杆菌 /
双歧杆菌四联活菌片 /
呋喃唑酮 /
四联疗法 /
新兵
Key words
helicobacter pylori /
bifidobacterium quadruple active tablets /
furazolidone /
quadruple therapy /
new recruits
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