目的 探讨慢性肾脏病(CKD)患者肌钙蛋白T(cTnT)与常见临床指标的依存关系,建立非透析CKD患者cTnT的校正公式。方法 回顾性分析690例中部战区总医院住院非透析CKD患者的临床指标:年龄、性别、基础代谢率(BMI)、估算肾小球滤过率(eGFR)、血肌酐(CR)、血尿酸(UA)、尿素(BUN)、白蛋白(ALB)、胆固醇(CHOL)、三酰甘油(TG)、血红蛋白(HGB)、红细胞比容(HCT)、红细胞分布宽度(RDW)、红细胞计数(RBC)、CKD分期;将cTnT值取对数为ln(cTnT),探讨以上指标与ln(cTnT)的依存关系,建立cTnT的校正公式。结果 cTnT的异常率随着CKD分期的上升逐渐升高。CKD各期的cTnT水平差异具有统计学意义(P＜0.05);ln(cTnT)与CR、UA、BUN、HGB、ALB、HCT、RDW、RBC、CKD分期、年龄、eGFR存在线性相关(P＜0.05);其中与CR、HGB、HCT、RBC、CKD分期存在强相关性(｜R｜＞0.5)。采用逐步多元线性回归分析,cTnT最终校正公式为cTnT校=0.0124*1.3366CKD*0.9931HGB。结论 临床排查非透析CKD患者的急性冠脉综合征(ACS)时,可将cTnT检测值与cTnT校正比较后再进行判断。
Abstract
Objective To investigatethe relationshipbetween troponin T (cTnT) and common clinical indicators in patients with chronic kidney disease (CKD), and to establish a correction formula for cTnT in non-dialysis CKD patients. Methods TheClinical indicators of 690 non-dialysis hospitalized CKD patients were retrospectively analyzed,including age, sex, basal metabolic rate (BMI), estimated glomerular filtration rate (eGFR), serum creatinine (CR), serum uric acid (UA), blood urea nitrogen (BUN), albumin (ALB), cholesterol (CHOL), triglyceride (TG), hemoglobin (HGB), hematocrit (HCT), red blood cell distribution width (RDW), red blood cell count (RBC), CKD stage. The logarithm of cTnT value was taken as ln(cTnT), the dependence between ln (cTnT) and the above indexes was discussed, and the correction formula of cTnT was established. Results The abnormal rate of cTnT increased gradually with the increase of CKD stage. The cTnT levels of each stage of CKD were significantly different (P<0.05). ln(cTnT) was linearly correlated with CR, UA, BUN, HGB, ALB, HCT, RDW, RBC, CKD stage, age and eGFR (P<0.05). With CR, HGB, HCT, RBC, CKD stage there was strong correlation(| R | >0.5). Stepwise multiple linear regression analysis was adopted, and the final correction formula was cTnTcalibration=0.0124×1.3366CKD×0.9931HGB. Conclusions In the clinical investigation of acute coronary syndrome(ACS) in non-dialysis CKD patients, cTnT detection value can be compared with cTnT calibration before judgment.
关键词
慢性肾脏病 /
肌钙蛋白T /
校正公式 /
逐步多元线性回归
Key words
chronic kidney disease /
troponin T /
correction formula /
stepwise multiple linear regression
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基金
中部战区总医院育英计划项目(ZZYFH202120)
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