目的 探讨壳聚糖止血粉治疗浅表皮肤损伤的疗效。方法 选择2019-06至2022-05在特战、机动集训中发生浅表皮肤损伤的战士102名为研究对象,根据证件号随机分成试验组和对照组,并根据不同的损伤部位分别分为手伤和体伤,两组伤员均由卫生人员进行规范的创面处理并应用碘伏,暴露患处,此外,试验组在创面上敷用壳聚糖止血粉,自然结痂,干性愈合。比较试验组施用碘伏和壳聚糖时的VAS评分,比较不同损伤部位下两组人员的创面硬痂形成时间和痂皮脱落时间。结果 应用壳聚糖止血粉后疼痛程度轻,耐受性好,手伤试验组的结痂时间[(12.89±5.33)h]明显短于手伤对照组[(16.36±4.77)h],差异有统计学意义(P＜0.05)。体伤试验组结痂时间[(21.14±10.38)h]、脱痂时间[(15.14±1.51)d]明显短于对照组[(28.50±11.86)h、(17.44±2.25)d],差异有统计学意义(P＜0.05)。结论 壳聚糖止血粉治疗部队常见的浅表皮肤损伤,结痂快,疼痛小,愈合快。
Abstract
Objective To investigate the efficacy of chitosan hemostatic powder in the treatment of superficial skin injury in officers and soldiers. Methods A total of 102 soldiers who suffered superficial skin injuries during special operations and mobile training from June 2019 to May 2022 were randomly divided into test group and control group according to their certificate number, and were also divided into hand injury group and body injury group according to different injury sites. The wounded in all the groups were treated with iodophor and exposed to the affected areas. The test group was treated with chitosan hemostatic powder to form scabs naturally for dry healing. The pain of the patients treated with iodophor and chitosan was compared, and the time of scab formation and scab shedding was compared between the two groups under different injury sites. Results After the application of chitosan hemostatic powder, the pain degree was mild and the tolerance was good. The duration of scab in the hand injury test group [(12.89±5.33) h]was significantly shorter than that in the hand injury control group[ (16.36±4.77) h], and the difference was statistically significant (P<0.05). The duration of scab formation[ (21.14±10.38) h] and the duration of scab removal[(15.14±1.51 ) d] in the body injury test group were significantly shorter than those in the control group[(28.50±11.86) h and (17.44±2.25) d], and the difference was statistically significant (P<0.05). Conclusions Chitosan hemostatic powder is effective in the treatment of superficial skin, which is characterized by fast scab, less pain and fast healing.
关键词
部队 /
浅表皮肤损伤 /
壳聚糖
Key words
army force /
superficial skin injury /
chitosan
{{custom_sec.title}}
{{custom_sec.title}}
{{custom_sec.content}}
参考文献
[1] Patrulea V, Ostafe V, Borchard G, et al. Chitosan as a starting material for wound healing applications[J]. Eur J Pharm Biopharm, 2015,97(Pt B):417-426.
[2] Liu H, Wang C, Li C, et al. A functional chitosan-based hydrogel as a wound dressing and drug delivery system in the treatment of wound healing[J]. RSC Adv, 2018,8(14):7533-7549.
[3] Hosseinnejad M, Jafari S M. Evaluation of different factors affecting antimicrobial properties of chitosan[J]. Int J Biol Macromol, 2016, 85:467-475.
[4] Chung Y J, An S Y, Yeon J Y, et al. Effect of a chitosan gel on hemostasis and prevention of adhesion after endoscopic sinus surgery[J]. Clin Exp Otorhinolaryngol, 2016, 9(2):143-149.
[5] Azad A K, Sermsintham N, Chandrkrachang S, et al. Chitosan membrane as a wound-healing dressing: characterization and clinical application[J]. J Biomed Mater Res B Appl Biomater, 2004,69(2):216-222.
[6] Halim A S, Nor F M, Mat Saad A Z, et al. Efficacy of chitosan derivative films versus hydrocolloid dressing on superficial wounds[J]. J Taibah Univ Med Sci, 2018,13(6):512-520.
[7] Bachtell N, Goodell T, Grunkemeier G, et al. Treatment of dialysis access puncture wound bleeding with chitosan dressings[J]. Dial Transpl, 2010,35(11):672-681.
[8] Campani V, Pagnozzi E, Mataro I, et al. Chitosan gel to treat pressure ulcers: a clinical pilot study[J]. Pharmaceutics, 2018,10(1):12-20.
[9] Wedmore I, McManus J G, Pusateri A E, et al. A special report on the chitosan-based hemostatic dressing: experience in current combat operations[J]. J Trauma, 2006, 60(3): 655-658.
[10] Te Grotenhuis R, van Grunsven P M, Heutz W M, et al. Prehospital use of hemostatic dressings in emergency medical services in the Netherlands: a prospective study of 66 cases[J]. Injury, 2016,47(5):1007-1011.
[11] Otrocka-Domagała I, Jastrzębski P, Adamiak Z, et al. Safety of the long-term application of Quik Clot Combat Gauze, ChitoGauze PRO and Celox Gauze in a femoral artery injury model in swine-a preliminary study[J]. Pol J Vet Sci, 2016,19(2):337-343.
[12] Haque M I, Beekley A C, Gutowska A, et al. Bioabsorption qualities of chitosan-absorbable vascular templates(1)[J]. Curr Surg, 2001,58(1):77-80.
PDF(987 KB)
